Rocchi Laura, Palmerini Luca, Weiss Aner, Herman Talia, Hausdorff Jeffrey M
IEEE Trans Neural Syst Rehabil Eng. 2014 Sep;22(5):1064-71. doi: 10.1109/TNSRE.2013.2292496. Epub 2013 Dec 5.
In this study, the use of an instrumented balance test based on inertial sensors was evaluated in patients with Parkinson's disease (PD). We aimed to objectively characterize motor subtypes of PD [tremor dominant (TD) and postural instability gait difficulty (PIGD)], to help to quantitatively classify the PD subjects into motor subtypes. Subjects were studied performing postural tests, while wearing a device including a tri-axial accelerometer on the lower back, in four different experimental conditions that depended on feet position (feet-together or semi-tandem) and vision (eyes open or closed). Postural measures, after a reliability check, were tested to identify their sensitivity to the disease, to the PD subtypes, and to the experimental conditions. The results highlight the possibility of distinguishing between the TD and PIGD subtypes by means of objective postural measures that are able to detect tremor and PIGD features and are able to classify a subject as TD or PIGD with good accuracy. Feet position influences frequency measures, whereas eyes closure influences the displacement measures and enhances differences between PD and control subjects, suggesting that postural displacement measures may be capable of detecting different adaptation processes to external sensory conditions between patients with PD and control subjects.
在本研究中，我们对帕金森病（PD）患者使用基于惯性传感器的仪器化平衡测试进行了评估。我们旨在客观地描述PD的运动亚型[震颤为主型（TD）和姿势不稳步态障碍型（PIGD）]，以帮助将PD受试者定量分类为运动亚型。研究对象在进行姿势测试时，佩戴一种在下背部装有三轴加速度计的设备，测试在四种不同的实验条件下进行，这四种条件取决于双脚位置（双脚并拢或半串联）和视觉状态（睁眼或闭眼）。在进行可靠性检查后，对姿势测量结果进行测试，以确定其对疾病及其亚型以及实验条件的敏感性。结果表明，通过能够检测震颤和PIGD特征且能以较高准确率将受试者分类为TD或PIGD的客观姿势测量方法，有可能区分TD和PIGD亚型。双脚位置影响频率测量，而闭眼则影响位移测量，并增强了PD患者与对照受试者之间的差异，这表明姿势位移测量可能能够检测出PD患者与对照受试者在对外界感觉条件的不同适应过程。
