Fléchard Maud, Gilot Philippe
Biochimie et Génétique Moléculaire Bactérienne, Institut des Sciences de la Vie, Université Catholique de Louvain, B-1348 Louvain-la-Neuve, Belgium.
INRA, UMR1282 Infectiologie et Santé Publique, F-37380 Nouzilly, France.
Microbiology (Reading). 2014 Jul;160(Pt 7):1298-1315. doi: 10.1099/mic.0.077628-0. Epub 2014 Apr 23.
We have referenced and described Streptococcus agalactiae transposable elements encoding DDE transposases. These elements belonged to nine families of insertion sequences (ISs) and to a family of conjugative transposons (TnGBSs). An overview of the physiological impact of the insertion of all these elements is provided. DDE-transposable elements affect S. agalactiae in a number of aspects of its capability to adapt to various environments and modulate the expression of several virulence genes, the scpB-lmB genomic region and the genes involved in capsule expression and haemolysin transport being the targets of several different mobile elements. The referenced mobile elements modify S. agalactiae behaviour by transferring new gene(s) to its genome, by modifying the expression of neighbouring genes at the integration site or by promoting genomic rearrangements. Transposition of some of these elements occurs in vivo, suggesting that by dynamically regulating some adaptation and/or virulence genes, they improve the ability of S. agalactiae to reach different niches within its host and ensure the 'success' of the infectious process.
我们已查阅并描述了编码DDE转座酶的无乳链球菌转座元件。这些元件属于九个插入序列（IS）家族和一个接合转座子（TnGBSs）家族。本文提供了所有这些元件插入的生理影响概述。DDE转座元件在无乳链球菌适应各种环境的能力以及调节多个毒力基因表达的多个方面对其产生影响，scpB - lmB基因组区域以及参与荚膜表达和溶血素转运的基因是几种不同移动元件的作用靶点。所查阅的移动元件通过向其基因组转移新基因、通过改变整合位点附近基因的表达或通过促进基因组重排来改变无乳链球菌的行为。其中一些元件的转座发生在体内，这表明通过动态调节一些适应性和/或毒力基因，它们提高了无乳链球菌在其宿主内到达不同生态位的能力，并确保感染过程的“成功”。
