Ahn Dong Ki, Moon Sang Ho, Kim Tae Woo, Boo Kyung Hwan, Hong Sung Won
Department of Orthopedic Surgery, Seoul Sacred Heart General Hospital, Seoul, Korea.
Asian Spine J. 2014 Apr;8(2):129-37. doi: 10.4184/asj.2014.8.2.129. Epub 2014 Apr 8.
A case controlled study with prospective data collection.
To evaluate the early influence and the final consequence of demineralized bone matrix (DBM) on auto-local bone as a graft enhancer in posterior lumbar interbody fusion (PLIF).
DBM is known as an osteoinductive material; however, it has not been clearly recognized to enhance auto-local bone with a small amount.
Patients who had a PLIF were allocated into two groups. Group I (70 cases) used auto-local bone chips and group II (44 cases) used DBM as an additive to auto-local bone, 1 mL per a segment. Group selection was alternated. Early assessment was performed by computed tomography at 6 months and final assessment was done by simple radiography after 24 months at least. The degree of bone formation was assessed by 4 grade scale.
The subjects of both groups were homogenous and had similar Oswestry Disability Index at final assessment. The ratio of auto-local bone chips and DBM was 6:1. The degree of bone formation at 6 months after surgery was superior in group II. However, there was no significant difference between the two groups at the final assessment.
DBM was not recognized to enhance auto-local bone with small amount.
一项采用前瞻性数据收集的病例对照研究。
评估脱矿骨基质（DBM）作为后路腰椎椎间融合术（PLIF）中自体局部骨移植增强剂的早期影响和最终结果。
DBM是一种已知的骨诱导材料；然而，其少量增强自体局部骨的作用尚未得到明确认识。
接受PLIF手术的患者被分为两组。第一组（70例）使用自体局部骨碎片，第二组（44例）使用DBM作为自体局部骨的添加剂，每节段1毫升。分组交替进行。早期评估在6个月时通过计算机断层扫描进行，最终评估至少在24个月后通过简单X线摄影进行。骨形成程度采用4级评分标准评估。
两组受试者具有同质性，最终评估时的奥斯维斯特里功能障碍指数相似。自体局部骨碎片与DBM的比例为6:1。术后6个月时第二组的骨形成程度更佳。然而，最终评估时两组之间无显著差异。
未发现DBM能少量增强自体局部骨。
