Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam-si 13620, Republic of Korea.
Department of Orthopaedic Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea.
Medicina (Kaunas). 2024 Feb 2;60(2):265. doi: 10.3390/medicina60020265.
: Posterior lumbar interbody fusion (PLIF) plays a crucial role in addressing various spinal disorders. The success of PLIF is contingent upon achieving bone fusion, as failure can lead to adverse clinical outcomes. Demineralized bone matrix (DBM) has emerged as a promising solution for promoting fusion due to its unique combination of osteoinductive and osteoconductive properties. This study aims to compare the effectiveness of three distinct DBMs (Exfuse, Bongener, and Bonfuse) in achieving fusion rates in PLIF surgery. : A retrospective review was conducted on 236 consecutive patients undergoing PLIF between September 2016 and February 2019. Patients over 50 years old with degenerative lumbar disease, receiving DBM, and following up for more than 12 months after surgery were included. Fusion was evaluated using the Bridwell grading system. Bridwell grades 1 and 2 were defined as 'fusion', while grades 3 and 4 were considered 'non-fusion.' Clinical outcomes were assessed using visual analog scale (VAS) scores for pain, the Oswestry disability index (ODI), and the European quality of life-5 (EQ-5D). : Fusion rates were 88.3% for Exfuse, 94.3% for Bongener, and 87.7% for Bonfuse, with no significant differences. All groups exhibited significant improvement in clinical outcomes at 12 months after surgery, but no significant differences were observed among the three groups. : There were no significant differences in fusion rates and clinical outcomes among Exfuse, Bongener, and Bonfuse in PLIF surgery.
后路腰椎体间融合术（PLIF）在治疗各种脊柱疾病中起着至关重要的作用。PLIF 的成功取决于是否能实现骨融合，因为失败可能会导致不良的临床结果。脱钙骨基质（DBM）具有成骨诱导和骨传导特性，是一种很有前途的促进融合的解决方案。本研究旨在比较三种不同的 DBM（Exfuse、Bongener 和 Bonfuse）在 PLIF 手术中实现融合率的效果。
对 2016 年 9 月至 2019 年 2 月期间接受 PLIF 的 236 例连续患者进行了回顾性研究。纳入标准为年龄大于 50 岁、患有退行性腰椎疾病、接受 DBM 治疗且术后随访 12 个月以上的患者。融合评估采用 Bridwell 分级系统。Bridwell 分级 1 和 2 定义为“融合”，分级 3 和 4 为“未融合”。采用视觉模拟评分（VAS）评估疼痛、Oswestry 功能障碍指数（ODI）和欧洲生活质量 5 维度（EQ-5D）评估临床结果。
Exfuse 组的融合率为 88.3%，Bongener 组为 94.3%，Bonfuse 组为 87.7%，差异无统计学意义。三组患者术后 12 个月临床结果均显著改善，但三组间无显著差异。
在 PLIF 手术中，Exfuse、Bongener 和 Bonfuse 之间的融合率和临床结果无显著差异。
