散斑对比光学层析成像：一种用于血流深度组织三维层析成像的新方法。
Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow.
作者信息
Varma Hari M, Valdes Claudia P, Kristoffersen Anna K, Culver Joseph P, Durduran Turgut
机构信息
ICFO-Institut de Ciències Fotòniques, Av. Carl Friedrich Gauss, 3, 08860, Castelldefels (Barcelona), Spain ; These authors contributed equally to this work.
ICFO-Institut de Ciències Fotòniques, Av. Carl Friedrich Gauss, 3, 08860, Castelldefels (Barcelona), Spain.
出版信息
Biomed Opt Express. 2014 Mar 28;5(4):1275-89. doi: 10.1364/BOE.5.001275. eCollection 2014 Apr 1.
Abstract
A novel tomographic method based on the laser speckle contrast, speckle contrast optical tomography (SCOT) is introduced that allows us to reconstruct three dimensional distribution of blood flow in deep tissues. This method is analogous to the diffuse optical tomography (DOT) but for deep tissue blood flow. We develop a reconstruction algorithm based on first Born approximation to generate three dimensional distribution of flow using the experimental data obtained from tissue simulating phantoms.
摘要
介绍了一种基于激光散斑对比度的新型层析成像方法——散斑对比度光学层析成像（SCOT），它使我们能够重建深部组织中血流的三维分布。该方法类似于漫射光学层析成像（DOT），但用于深部组织血流。我们基于一阶玻恩近似开发了一种重建算法，以利用从组织模拟体模获得的实验数据生成血流的三维分布。
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