Haria Dhwani, Naora Honami
Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, U.S.A.
Cancer Hallm. 2013 Sep 1;1(2-3):67-76. doi: 10.1166/ch.2013.1007.
Homeobox genes comprise a super-family of evolutionarily conserved genes that play essential roles in controlling body plan specification and cell fate determination. Substantial evidence indicates that leukemogenesis is driven by abnormal expression of homeobox genes that control hematopoiesis. In solid tumors, aberrant expression of homeobox genes has been increasingly found to modulate diverse processes such as cell proliferation, cell death, metastasis, angiogenesis and DNA repair. This review discusses how homeobox genes are deregulated in solid tumors and the functional significance of this deregulation in the hallmarks of cancer.
同源框基因构成了一个进化上保守的基因超家族，在控制身体模式特化和细胞命运决定中发挥着重要作用。大量证据表明，白血病的发生是由控制造血的同源框基因异常表达所驱动的。在实体瘤中，越来越多地发现同源框基因的异常表达会调节多种过程，如细胞增殖、细胞死亡、转移、血管生成和DNA修复。本文综述了同源框基因在实体瘤中是如何失调的，以及这种失调在癌症特征中的功能意义。
