Vinod R K, Shashikala M, Suresh K P
J Indian Med Assoc. 2013 Jun;111(6):391-4.
The objectives of the study were to determine dyslipidaemia prevalence in first episode coronary heart disease cases and to determine the pattern of distribution of risk factors in this temporal relationship. This hospital based retrospective cohort study was conducted at Basaveshwara Teaching Hospital, Gulbarga, during January 2012. Data for the 3 year period (January 2005-December 2007) were collected from the case sheets of cardiac care unit admissions. Out of the 1,373 admissions to the cardiac care unit over the 36 months period, 462 case sheets were examined as these were the ones with first episode coronary heart disease aetiology. Also, lipid profile was available for 102 patients only and hence they were included in the study (n = 102). Only first episode coronary heart disease cases were considered. The labelling of dyslipidaemia was done according to the National Cholesterol Education Program Adult Treatment Panel III guidelines. Statistical analysis was done using Fisher-Exact, Chi-square and other appropriate tests. Dyslipidaemia was present in 67.6% of first episode coronary heart disease cases. Age, sex and occupational profiles were enumerated and cross-tabulated to examine their influence on dyslipidaemia. In this study, increasing age profile did not show an association with the propensity towards developing an abnormal lipid profile. Males showed a greater predisposition towards developing dyslipidaemia (70.8%). With respect to occupation, males involved in semi-skilled labour had a higher degree of lipid profile abnormality (87.5%). Dyslipidaemia among working women was higher (75%) when compared to housewives (40%). This association was found to be statistically significant (p = 0.025). History of diabetes, hypertension, alcohol and smoking habits were also considered for the analysis. Heart disease patients with history of diabetes showed a high prevalence of dyslipidaemia (100%), the association being statistically significant (p = 0.008). Lipid profiling among hypertensives showed an aberration, wherein the prevalence of an abnormal profile was lower (54.5%). This association was found to be statistically significant (p=0.05). The influence of alcohol consumption on lipid profile showed an unequivocal association in this study (63.6%), when compared with patients who did not consume alcohol (69.6%). However, an association for dyslipidaemia was forthcoming among smokers (73.7%). This study shows significant association of dyslipidaemia with diabeties, history of alcohol consumption and the working profile of a woman.
该研究的目的是确定初发冠心病病例中的血脂异常患病率，并确定这种时间关系中危险因素的分布模式。这项基于医院的回顾性队列研究于2012年1月在古尔伯加的巴萨韦什瓦拉教学医院进行。收集了3年期间（2005年1月至2007年12月）心脏监护病房入院病例表中的数据。在36个月期间心脏监护病房的1373例入院病例中，检查了462份病例表，因为这些病例表的病因是初发冠心病。此外，只有102例患者有血脂谱数据，因此将他们纳入研究（n = 102）。仅考虑初发冠心病病例。血脂异常的判定依据美国国家胆固醇教育计划成人治疗专家组第三次报告的指南进行。使用Fisher精确检验、卡方检验和其他适当的检验进行统计分析。67.6%的初发冠心病病例存在血脂异常。对年龄、性别和职业概况进行了统计并交叉制表，以研究它们对血脂异常的影响。在这项研究中，年龄增长与出现异常血脂谱的倾向没有关联。男性患血脂异常的倾向更大（70.8%）。在职业方面，从事半熟练劳动的男性血脂谱异常程度更高（87.5%）。职业女性的血脂异常率（75%）高于家庭主妇（40%）。这种关联具有统计学意义（p = 0.025）。分析中还考虑了糖尿病史、高血压、饮酒和吸烟习惯。有糖尿病史的心脏病患者血脂异常患病率很高（100%），这种关联具有统计学意义（p = 0.008）。高血压患者的血脂谱存在异常，其中异常血脂谱的患病率较低（54.5%）。这种关联具有统计学意义（p = 0.05）。在这项研究中，饮酒对血脂谱的影响显示出明确的关联（63.6%），与不饮酒的患者（69.6%）相比。然而，吸烟者中血脂异常的关联也很明显（73.7%）。这项研究表明血脂异常与糖尿病、饮酒史和女性职业状况之间存在显著关联。
