Gude Dilip Chandra, Chennamsetty Sashidhar, Bansal Dharam Pal, Jha Ratan
J Indian Med Assoc. 2013 Jun;111(6):406-7.
Acute transverse myelitis is a well known neurological complication occurring in systemic lupus erythematosus. Many prior studies have shown a link between transverse myelitis and the presence of antiphospholipid antibodies. Earlier theories have linked thrombotic tendency to be the culprit in such manifestations but currently there is evidence to support other causative mechanisms. A case of a young female diagnosed as systemic lupus erythematosus has been reported who presented with acute transverse myelitis and was found to be seronegative for antiphospholipid antibody. It is important to pay heed to and accordingly treat complications like acute transverse myelitis that occur regardless of antiphospholipid antibody positivity in a systemic lupus erythematosus setting.
急性横贯性脊髓炎是系统性红斑狼疮中一种广为人知的神经并发症。许多先前的研究表明横贯性脊髓炎与抗磷脂抗体的存在之间存在联系。早期理论认为血栓形成倾向是此类表现的罪魁祸首，但目前有证据支持其他致病机制。据报道，有一名年轻女性被诊断为系统性红斑狼疮，她出现了急性横贯性脊髓炎，且抗磷脂抗体检测呈血清阴性。在系统性红斑狼疮的情况下，无论抗磷脂抗体是否呈阳性，都要注意并相应地治疗诸如急性横贯性脊髓炎等并发症，这一点很重要。
