Ghafouri-Fard Soudeh, Nekoohesh Leili, Motevaseli Elahe
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran E-mail :
Asian Pac J Cancer Prev. 2014;15(6):2395-403. doi: 10.7314/apjcp.2014.15.6.2395.
As the recurrence and mortality rates of bladder cancer are high, research is needed to find suitable biomarkers for early detection, evaluation of prognosis, and surveillance of drug responses. We performed a computerized search of the Medline/PubMed databases with the key words bladder cancer, biomarker, early detection, prognosis and drug response. Several markers were identified at DNA, RNA and protein levels with different sensitivities and specificities. Only a few of the potential bladder cancer biomarkers have been approved for clinical use. Efforts now should be concentrated on finding a panel of markers with acceptable sensitivity and specificity for early detection of bladder cancer.
由于膀胱癌的复发率和死亡率较高，需要开展研究以寻找适用于早期检测、预后评估及药物反应监测的生物标志物。我们使用关键词“膀胱癌”“生物标志物”“早期检测”“预后”及“药物反应”对Medline/PubMed数据库进行了计算机检索。在DNA、RNA和蛋白质水平鉴定出了几种具有不同敏感性和特异性的标志物。仅有少数潜在的膀胱癌生物标志物已获批用于临床。目前应集中精力寻找一组对膀胱癌早期检测具有可接受敏感性和特异性的标志物。
