Castro-Piñero José, Carbonell-Baeza Ana, Martinez-Gomez David, Gómez-Martínez Sonia, Cabanas-Sánchez Verónica, Santiago Catalina, Veses Ana M, Bandrés Fernando, Gonzalez-Galo Ana, Gomez-Gallego Félix, Veiga Oscar L, Ruiz Jonatan R, Marcos Ascensión
Department of Physical Education, School of Education, University of Cádiz, Puerto Real, Spain.
BMC Public Health. 2014 Apr 25;14:400. doi: 10.1186/1471-2458-14-400.
An objective diagnosis of sedentary behaviour as well as of the physical activity and fitness levels in youth and to better understand how lifestyle is associated with cardiovascular disease risk factors and other phenotypes is of clinical and public health interest, and might be informative for developing intervention studies focused on the promotion of physical activity in these population. The aim of this methodological paper is to describe the design and assessment in the UP&DOWN study.
METHODS/DESIGN: The UP&DOWN study is a multi-center follow-up design where 2225 Spanish primary and secondary schoolchildren from Cadiz and Madrid, respectively, as well as 110 Spanish adolescents with Down syndrome from Madrid and Toledo were recruited to be assessed. Nine main measurement categories are assessed: i) socio-demographic and early determinants; ii) environmental determinants; iii) physical activity and sedentary behaviour; iv) health-related fitness; v) blood pressure and resting heart rate; vi) mental health; vii) dietary patterns; viii) blood samples; and ix) genetic analysis. During the 3-yr follow-up study, socio-demographic and early determinants, and genetic analysis are only assessed in the first year. Blood sampling is assessed in the first year and the third year (2nd follow-up), and all the other measurements are assessed every year.
The findings of the UP&DOWN study may help the Health Information Systems and policy makers to identify the target population for primary prevention and health promotion policies, and to develop and test preventive strategies. Moreover, these data will allow following the trends at population level, as well as to modify/adapt/create new evidence-based physical activity guidelines at national level. The findings will also serve as a scientific platform for interventional studies.
对青少年的久坐行为、身体活动和健康水平进行客观诊断，并更好地了解生活方式与心血管疾病风险因素及其他表型之间的关联，具有临床和公共卫生意义，可能为开展针对促进这些人群身体活动的干预研究提供信息。本文的目的是描述UP&DOWN研究的设计和评估。
方法/设计：UP&DOWN研究采用多中心随访设计，分别招募了来自加的斯和马德里的2225名西班牙中小学生，以及来自马德里和托莱多的110名患有唐氏综合征的西班牙青少年进行评估。评估九个主要测量类别：i）社会人口统计学和早期决定因素；ii）环境决定因素；iii）身体活动和久坐行为；iv）与健康相关的体能；v）血压和静息心率；vi）心理健康；vii）饮食模式；viii）血液样本；ix）基因分析。在为期3年的随访研究中，社会人口统计学和早期决定因素以及基因分析仅在第一年进行评估。血液样本在第一年和第三年（第二次随访）进行评估，所有其他测量每年进行评估。
UP&DOWN研究的结果可能有助于健康信息系统和政策制定者确定初级预防和健康促进政策的目标人群，并制定和测试预防策略。此外，这些数据将有助于跟踪人群水平的趋势，以及在国家层面修改/调整/制定新的基于证据的身体活动指南。这些发现还将作为干预研究的科学平台。
