Department of Prevention, Rehabilitation and Sports Medicine, Technische Universitaet Muenchen, Klinikum rechts der Isar, Munich, Germany.
BMC Public Health. 2011 Apr 22;11:258. doi: 10.1186/1471-2458-11-258.
Childhood obesity is not only associated with adult obesity but also with increased risk of adult onset of type 2 diabetes and subsequent coronary heart disease. The potential effects of school-based health intervention programmes on cardiovascular risk and surrogate markers are unclear, as only few studies have attempted to investigate a complete risk profile including a detailed laboratory analysis or micro- and macrovascular function. In this study a comprehensive school-based randomized intervention programme will be investigated in 10-14-year old children addressing the influence of lifestyle intervention on inactivity, cardiometabolic risk factors and early signs of vascular disease.
METHODS/DESIGN: 15 secondary schools in Southern Germany are randomly assigned to intervention or control schools. Children in the fifth grade (10-11 years) will be observed over four years. The study combines a school-based with a home-based approach, aiming at children, teachers and parents. The main components are weekly lifestyle-lessons for children, taught by regular classroom teachers to increase physical activity in- and outside of school, to improve eating patterns at school and at home, to reduce media consumption and to amplify well-being. In 4-6 annual meetings, teachers receive information about health-related topics with worksheets for children and supporting equipment, accounting for school-specific needs and strategies. Parents' trainings are provided on a regular basis.All examinations are performed at the beginning and at the end of every school year. Anthropometry includes measurements of BMI, waist and upper arm circumferences, skinfold thickness as well as peripheral blood pressure. Blood sampling includes lipid parameters, insulin, glucose, hsCRP, adiponectin, and IL-6 as well as testosteron and estrogen to determine maturation status. Vascular function is non-invasively assessed by measuring arterial stiffness in large arteries using a sphygmograph and by analysing arteriolar and venular diameters in the retinal microcirculation using a non-mydriatric vessel analyser. A questionnaire is filled out to determine daily physical activity, motivational factors, dietary habits, quality of life (KINDL-R) and socio-economic data. Physical fitness is assessed by a six-item test battery.
Our study aims to provide a feasible long-term intervention strategy to re-establish childhood health and to prevent obesity-related cardiovascular dysfunction in children.
NCT00988754.
儿童肥胖不仅与成人肥胖有关，而且还与成年后 2 型糖尿病发病风险增加以及随后的冠心病有关。基于学校的健康干预计划对心血管风险和替代标志物的潜在影响尚不清楚，因为只有少数研究试图调查包括详细实验室分析或微血管和大血管功能在内的完整风险概况。在这项研究中，将在 10-14 岁的儿童中调查一项全面的基于学校的随机干预计划，该计划针对生活方式干预对不活动、心血管代谢危险因素和血管疾病早期迹象的影响。
方法/设计：德国南部的 15 所中学被随机分配到干预组或对照组。五年级（10-11 岁）的儿童将在四年内进行观察。该研究结合了基于学校的和基于家庭的方法，针对儿童、教师和家长。主要组成部分是每周为儿童提供的生活方式课程，由常规课堂教师教授，以增加校内和校外的体育活动，改善学校和家庭的饮食模式，减少媒体消费，并提高幸福感。在 4-6 次年度会议中，教师将获得有关健康相关主题的信息，包括儿童工作表和支持设备，以满足学校特定的需求和策略。定期为家长提供培训。所有检查均在每个学年开始和结束时进行。人体测量学包括 BMI、腰围和上臂围、皮褶厚度以及外周血压的测量。血液采样包括血脂参数、胰岛素、葡萄糖、hsCRP、脂联素和 IL-6 以及睾酮和雌激素，以确定成熟状态。血管功能通过使用血压计无创地评估大动脉的动脉僵硬度，并通过使用非散瞳血管分析仪分析视网膜微循环中的小动脉和小静脉直径来评估。填写一份问卷，以确定日常体育活动、动机因素、饮食习惯、生活质量（KINDL-R）和社会经济数据。通过六项测试电池评估体能。
我们的研究旨在提供一种可行的长期干预策略，以恢复儿童健康并预防儿童肥胖相关的心血管功能障碍。
NCT00988754。
