Science. 2014 Apr 25;344(6182):380-6. doi: 10.1126/science.1249656.
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
采采蝇是整个撒哈拉以南非洲地区人类非洲锥虫病的唯一传播媒介。成年采采蝇的雌雄两性均专门以血液为食，并有助于疾病传播。采采蝇与其他病媒的显著区别包括专性微生物共生、胎生繁殖和哺乳。在这里，我们描述了 366 兆碱基的 Glossina morsitans morsitans 基因组的序列和注释。对基因组和 12308 个预测的蛋白质编码基因的分析导致了多项发现，包括细菌（沃尔巴克氏体）基因组序列的染色体整合、一个哺乳特异性蛋白家族、宿主病原体识别蛋白的补充减少，以及嗅觉/化学感觉相关基因的减少。这些基因组数据为研究锥虫病的预防提供了基础，并为采采蝇生物学的多个方面提供了重要的见解。
