Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Nationalestraat 155, B-2000, Antwerp, Belgium.
Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Nationalestraat 155, B-2000, Antwerp, Belgium.
Dev Comp Immunol. 2019 Sep;98:181-188. doi: 10.1016/j.dci.2019.05.003. Epub 2019 May 7.
Tsetse flies (Glossina sp.) are medically and veterinary important vectors of African trypanosomes, protozoan parasites that cause devastating diseases in humans and livestock in sub-Saharan Africa. These flies feed exclusively on vertebrate blood and harbor a limited diversity of obligate and facultative bacterial commensals. They have a well-developed innate immune system that plays a key role in protecting the fly against invading pathogens and in modulating the fly's ability to transmit African trypanosomes. In this review, we briefly summarize our current knowledge on the tsetse fly innate immune system and its interaction with the bacterial commensals and the trypanosome parasite.
采采蝇（ Glossina sp.）是医学和兽医上重要的非洲锥虫传播媒介，这种原生动物寄生虫会在撒哈拉以南的非洲地区给人类和牲畜带来毁灭性的疾病。这些苍蝇专门以脊椎动物的血液为食，并且携带有限的专性和兼性共生细菌。它们拥有一个完善的先天免疫系统，这个系统在保护苍蝇免受入侵病原体的侵害和调节苍蝇传播非洲锥虫的能力方面发挥着关键作用。在这篇综述中，我们简要总结了我们目前对采采蝇先天免疫系统及其与共生细菌和锥虫寄生虫相互作用的了解。
