正常子宫内膜、子宫内膜增生及腺癌中与单克隆抗体HMFG1和HMFG2的反应模式。

Patterns of reactivity with the monoclonal antibodies HMFG1 and HMFG2 in normal endometrium, endometrial hyperplasia and adenocarcinoma.

作者信息

Morris W P, Griffin N R, Wells M

机构信息

Department of Pathology, University of Leeds, UK.

出版信息

Histopathology. 1989 Aug;15(2):179-86. doi: 10.1111/j.1365-2559.1989.tb03065.x.

DOI:10.1111/j.1365-2559.1989.tb03065.x

PMID:2476372

Abstract

Using an indirect immunoperoxidase technique the expression of the epitopes in human milk fat globule (HMFG) membranes detected by the monoclonal antibodies HMFG1 and HMFG2 was studied in the normal endometrium and in cases of cystic glandular hyperplasia, glandular hyperplasia with architectural atypia (complex hyperplasia), glandular hyperplasia with cytological atypia (atypical hyperplasia) and invasive adenocarcinoma. Luminal reactivity with HMFG1 was seen in cases of normal endometrium, cystic glandular hyperplasia and glandular hyperplasia with architectural atypia. In contrast most cases of glandular hyperplasia with cytological atypia and invasive adenocarcinoma also showed areas of cytoplasmic reactivity. Reactivity with HMFG2 was scanty.

摘要

采用间接免疫过氧化物酶技术，研究了单克隆抗体HMFG1和HMFG2所检测的人乳脂肪球（HMFG）膜上抗原决定簇在正常子宫内膜、囊性腺增生、具有结构异型性的腺增生（复杂性增生）、具有细胞学异型性的腺增生（非典型增生）及浸润性腺癌中的表达情况。在正常子宫内膜、囊性腺增生及具有结构异型性的腺增生病例中可见与HMFG1的管腔反应性。相比之下，大多数具有细胞学异型性的腺增生及浸润性腺癌病例也显示出细胞质反应区域。与HMFG2的反应性较弱。