上皮膜抗原在正常和异常子宫内膜组织中的分布。

Distribution of epithelial membrane antigen in normal and abnormal endometrial tissue.

作者信息

Morse A R, Curran G J

出版信息

Br J Obstet Gynaecol. 1985 Dec;92(12):1286-90. doi: 10.1111/j.1471-0528.1985.tb04877.x.

DOI:10.1111/j.1471-0528.1985.tb04877.x

Abstract

The distribution of epithelial membrane antigen (EMA) on normal and abnormal endometrial tissue was studied as a method for distinguishing atypical hyperplasia from adenocarcinoma. Histological sections from 47 patients (nine adenocarcinoma, nine atypical hyperplasia, nine cystic hyperplasia, 19 normal endometrium and one sarcoma) were studied with an immunocytochemical alkaline phosphatase technique that demonstrated EMA. At a dilution of 1:1000 the majority of normal tissue was negative whereas all the abnormal tissue stained positively. At a slightly higher dilution all adenocarcinomas expressed the antigen although only a few of the hyperplastic lesions (16%) stained with the antibody. The value of this approach for automated screening is discussed.

摘要

研究了上皮膜抗原（EMA）在正常和异常子宫内膜组织上的分布，作为鉴别非典型增生与腺癌的一种方法。采用免疫细胞化学碱性磷酸酶技术对47例患者（9例腺癌、9例非典型增生、9例囊性增生、19例正常子宫内膜和1例肉瘤）的组织切片进行研究，该技术可显示EMA。在1:1000的稀释度下，大多数正常组织呈阴性，而所有异常组织均呈阳性染色。在稍高的稀释度下，所有腺癌均表达该抗原，尽管只有少数增生性病变（16%）被抗体染色。讨论了这种方法用于自动筛查的价值。