Yilmaz A, Yilmaz N, Serarslan Y, Aras M, Altas M, Özgür T, Sefil F
Clinic of Neurosurgery Bayburt, Bayburt State Hospital, II, Bayburt, Turkey.
Eur Rev Med Pharmacol Sci. 2014;18(7):992-1000.
The concern about mobile phone effects is increasing as the number of users increasing too. Different studies have different results, so this topic is still open to discussion. Aim of this report was to investigate the effects of the mobile phones on the Bcl-2 gene and p53 proteins in rat brains.
In the study group of 10 rats; mobile phones that spread EMW at a frequency between 1900-2100 MHz and Specific Absorption Rate range between 0.005 W/kg and 0.288 W/kg (Dialing mode), 0.004 W/kg and 0.029 W/kg (Calling mode) were attached to rat ears for simulating usage in daily life for 7 times a day during 5 minutes (3 seconds dialing mode, 4 minutes and 47 seconds of calling mode) for a four week period. Sham group (n=10) rats were only immobilized without EMW exposure. Another group of rats (n=10) were counted as control without any application. immunohistopathological examination was performed for p53 and Bcl-2 expression.
Immunohistopathological examinations revealed that the samples in the study group had more p53 and Bcl-2 positive stained cells and they were stained denser. In both evaluations, these differences between the study and control group were found statistically significant (p < 0.003); In Bcl-2 evaluation statistically significant difference was found between study and sham group to (p < 0.005); however, the p53 evaluation between the study and the sham group did not show any statistically significant difference (p > 0.005).
Our results showed that the electro-magnetic waves emitted by the mobile phones may have effect on apoptosis. Besides, obtained data revealed that more realistic application of mobile phones during experiments is more important as expected.
随着手机用户数量的增加，人们对手机影响的担忧也在增加。不同的研究有不同的结果，因此这个话题仍有待讨论。本报告的目的是研究手机对大鼠大脑中Bcl-2基因和p53蛋白的影响。
在10只大鼠的研究组中；将发射频率在1900 - 2100 MHz、比吸收率范围在0.005 W/kg至0.288 W/kg（拨号模式）、0.004 W/kg至0.029 W/kg（通话模式）的手机贴在大鼠耳朵上，模拟日常生活中的使用情况，每天7次，每次5分钟（3秒拨号模式，4分47秒通话模式），持续四周。假手术组（n = 10）的大鼠仅被固定，不暴露于电磁辐射。另一组大鼠（n = 10）作为未进行任何处理的对照组。对p53和Bcl-2表达进行免疫组织病理学检查。
免疫组织病理学检查显示，研究组的样本中有更多p53和Bcl-2阳性染色细胞，且染色更密集。在两项评估中，研究组与对照组之间的这些差异均具有统计学意义（p < 0.003）；在Bcl-2评估中，研究组与假手术组之间也存在统计学意义上的显著差异（p < 0.005）；然而，研究组与假手术组之间的p53评估未显示任何统计学意义上的显著差异（p > 0.005）。
我们的结果表明，手机发出的电磁波可能对细胞凋亡有影响。此外，获得的数据表明，实验期间更真实地使用手机如预期的那样更为重要。
