通过针对荚膜多糖的单克隆抗体检测到新型隐球菌血清型内的抗原变异。
Antigenic variation within serotypes of Cryptococcus neoformans detected by monoclonal antibodies specific for the capsular polysaccharide.
作者信息
Spiropulu C, Eppard R A, Otteson E, Kozel T R
机构信息
Department of Microbiology, University of Nevada, Reno 89557.
出版信息
Infect Immun. 1989 Oct;57(10):3240-2. doi: 10.1128/iai.57.10.3240-3242.1989.
Abstract
The serotype-specific polysaccharide was isolated from four to seven strains of each of the four major serotypes of Cryptococcus neoformans. Reactivities of polysaccharides with seven monoclonal antibodies raised against polysaccharides of serotypes A, B, C, and D were assessed by an enzyme-linked immunosorbent assay and double immunodiffusion. The results indicated that there is heterogeneity within all four serotypes in the expression of epitopes reactive with monoclonal antibodies.
摘要
新型隐球菌四种主要血清型中，每种血清型从四到七株菌株中分离出血清型特异性多糖。通过酶联免疫吸附测定和双向免疫扩散法评估这些多糖与针对A、B、C和D血清型多糖产生的七种单克隆抗体的反应性。结果表明，在所有四种血清型中，与单克隆抗体反应的表位表达存在异质性。
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