• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia.单核细胞趋化蛋白-1/CCL2在胃癌中的表达及其与肿瘤缺氧的关系。
World J Gastroenterol. 2014 Apr 21;20(15):4421-7. doi: 10.3748/wjg.v20.i15.4421.
2
Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma.CD73 和缺氧诱导因子-1α 在胃癌中的表达及临床意义。
World J Gastroenterol. 2013 Mar 28;19(12):1912-8. doi: 10.3748/wjg.v19.i12.1912.
3
Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer.缺氧诱导因子-1α和脯氨酰 4-羟化酶β多肽过表达在胃癌中的预后价值。
World J Gastroenterol. 2018 Jun 14;24(22):2381-2391. doi: 10.3748/wjg.v24.i22.2381.
4
[Expression of hypoxia-inducible factor 1α in gastric cancer and its clinical signficance].[缺氧诱导因子1α在胃癌中的表达及其临床意义]
Zhonghua Yi Xue Za Zhi. 2016 May 17;96(18):1418-23. doi: 10.3760/cma.j.issn.0376-2491.2016.18.007.
5
Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.RAP1B的表达与胃癌预后不良相关，并促进其侵袭性表型。
Oncol Rep. 2015 Nov;34(5):2385-94. doi: 10.3892/or.2015.4234. Epub 2015 Sep 1.
6
HIF-1 alpha overexpression correlates with poor overall survival and disease-free survival in gastric cancer patients post-gastrectomy.缺氧诱导因子-1α（HIF-1α）过表达与胃癌患者胃切除术后的总生存期和无病生存期较差相关。
PLoS One. 2014 Mar 10;9(3):e90678. doi: 10.1371/journal.pone.0090678. eCollection 2014.
7
CCL2 expression correlates with Snail expression and affects the prognosis of patients with gastric cancer.CCL2的表达与Snail的表达相关，并影响胃癌患者的预后。
Pathol Res Pract. 2017 Mar;213(3):217-221. doi: 10.1016/j.prp.2016.12.013. Epub 2016 Dec 23.
8
The expression of HIF-1α in primary hepatocellular carcinoma and its correlation with radiotherapy response and clinical outcome.HIF-1α 在原发性肝细胞癌中的表达及其与放疗反应和临床结局的相关性。
Mol Biol Rep. 2012 Feb;39(2):2021-9. doi: 10.1007/s11033-011-0949-1. Epub 2011 Jun 7.
9
Increased expression of C-C motif ligand 2 associates with poor prognosis in patients with gastric cancer after gastrectomy.C-C基序配体2表达增加与胃癌患者胃切除术后预后不良相关。
Tumour Biol. 2016 Mar;37(3):3285-93. doi: 10.1007/s13277-015-4092-9. Epub 2015 Oct 5.
10
Semaphorin 4D and hypoxia-inducible factor-1α overexpression is related to prognosis in colorectal carcinoma.信号素4D和缺氧诱导因子-1α的过表达与结直肠癌的预后相关。
World J Gastroenterol. 2015 Feb 21;21(7):2191-8. doi: 10.3748/wjg.v21.i7.2191.

引用本文的文献

1
Network pharmacology study and experimental validation of Xiaojianzhong decoction against gastric cancer.小建中汤抗胃癌的网络药理学研究及实验验证
World J Gastrointest Oncol. 2024 Sep 15;16(9):3932-3954. doi: 10.4251/wjgo.v16.i9.3932.
2
Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas.解读胶质母细胞瘤：对胶质瘤生物学和治疗策略的基础与新见解
Curr Issues Mol Biol. 2024 Mar 13;46(3):2402-2443. doi: 10.3390/cimb46030153.
3
Application progress of liquid biopsy in gastric cancer.液体活检在胃癌中的应用进展
Front Oncol. 2022 Sep 15;12:969866. doi: 10.3389/fonc.2022.969866. eCollection 2022.
4
The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer.缺氧诱导因子-1α作为胃癌特征的强效诱导剂。
Cancers (Basel). 2022 May 30;14(11):2711. doi: 10.3390/cancers14112711.
5
Therapeutic Targeting Hypoxia-Inducible Factor (HIF-1) in Cancer: Cutting Gordian Knot of Cancer Cell Metabolism.癌症中针对缺氧诱导因子（HIF-1）的治疗靶向：解开癌细胞代谢的戈尔迪之结
Front Genet. 2022 Mar 31;13:849040. doi: 10.3389/fgene.2022.849040. eCollection 2022.
6
Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype.RNA 结合蛋白 HuD 的缺失促进了衰老相关分泌表型的产生。
Cell Death Dis. 2022 Apr 11;13(4):329. doi: 10.1038/s41419-022-04792-y.
7
Uncovering the Mechanisms and Molecular Targets of Weibing Formula 1 against Gastritis: Coupling Network Pharmacology with GEO Database.揭示胃卫兵 1 号治疗胃炎的作用机制及分子靶点：基于网络药理学结合 GEO 数据库分析。
Biomed Res Int. 2021 Aug 21;2021:5533946. doi: 10.1155/2021/5533946. eCollection 2021.
8
Role of the CCL2-CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting.CCL2-CCR2 信号轴在癌症中的作用：机制与治疗靶点。
Cell Prolif. 2021 Oct;54(10):e13115. doi: 10.1111/cpr.13115. Epub 2021 Aug 31.
9
Is the C-C Motif Ligand 2-C-C Chemokine Receptor 2 Axis a Promising Target for Cancer Therapy and Diagnosis?C-C 基序趋化因子配体 2-C-C 趋化因子受体 2 轴是癌症治疗和诊断的有前途的靶点吗？
Int J Mol Sci. 2020 Dec 7;21(23):9328. doi: 10.3390/ijms21239328.
10
The Role of Chemokines in the Development of Gastric Cancer - Diagnostic and Therapeutic Implications.趋化因子在胃癌发展中的作用——诊断和治疗意义。
Int J Mol Sci. 2020 Nov 10;21(22):8456. doi: 10.3390/ijms21228456.

本文引用的文献

1
S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages.S100B 通过趋化髓系来源的巨噬细胞促进神经胶质瘤生长。
Clin Cancer Res. 2013 Jul 15;19(14):3764-75. doi: 10.1158/1078-0432.CCR-12-3725. Epub 2013 May 29.
2
Inhibition of CCL2 signaling in combination with docetaxel treatment has profound inhibitory effects on prostate cancer growth in bone.CCL2信号传导的抑制与多西他赛治疗相结合，对骨内前列腺癌的生长具有深远的抑制作用。
Int J Mol Sci. 2013 May 21;14(5):10483-96. doi: 10.3390/ijms140510483.
3
Gastric cancer: epidemiology and risk factors.胃癌：流行病学和危险因素。
Gastroenterol Clin North Am. 2013 Jun;42(2):219-40. doi: 10.1016/j.gtc.2013.01.003. Epub 2013 Mar 29.
4
Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells.基质细胞产生的单核细胞趋化蛋白-1/CCL2 促进 4T1 鼠乳腺癌细胞的肺转移。
PLoS One. 2013;8(3):e58791. doi: 10.1371/journal.pone.0058791. Epub 2013 Mar 18.
5
Relationships of single nucleotide polymorphisms of monocyte chemoattractant protein 1 and chemokine receptor 2 with susceptibility and clinicopathologic characteristics of neoplasia of uterine cervix in Taiwan women.台湾女性中单核细胞趋化蛋白 1 和趋化因子受体 2 的单核苷酸多态性与宫颈癌易感性及临床病理特征的关系。
Reprod Sci. 2013 Oct;20(10):1175-83. doi: 10.1177/1933719113477481. Epub 2013 Feb 20.
6
Hypoxia-mediated regulation of macrophage functions in pathophysiology.缺氧介导的巨噬细胞功能在病理生理学中的调节。
Int Immunol. 2013 Feb;25(2):67-75. doi: 10.1093/intimm/dxs110. Epub 2012 Nov 24.
7
Gastric cancer epidemiology and risk factors.胃癌的流行病学和危险因素。
J Surg Oncol. 2013 Mar;107(3):230-6. doi: 10.1002/jso.23262. Epub 2012 Nov 5.
8
Tumor associated macrophages and neutrophils in tumor progression.肿瘤相关巨噬细胞和中性粒细胞在肿瘤进展中的作用。
J Cell Physiol. 2013 Jul;228(7):1404-12. doi: 10.1002/jcp.24260.
9
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.CCL2 招募炎症性单核细胞以促进乳腺癌转移。
Nature. 2011 Jun 8;475(7355):222-5. doi: 10.1038/nature10138.
10
CCL2 blockade augments cancer immunotherapy.CCL2 阻断增强癌症免疫疗法。
Cancer Res. 2010 Jan 1;70(1):109-18. doi: 10.1158/0008-5472.CAN-09-2326. Epub 2009 Dec 22.

单核细胞趋化蛋白-1/CCL2在胃癌中的表达及其与肿瘤缺氧的关系。

Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia.

作者信息

Tao Lei-Lei, Shi Shu-Jing, Chen Long-Bang, Huang Gui-Chun

机构信息

Lei-Lei Tao, Shu-Jing Shi, Long-Bang Chen, Gui-Chun Huang, Medical Oncology Department of Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.

出版信息

World J Gastroenterol. 2014 Apr 21;20(15):4421-7. doi: 10.3748/wjg.v20.i15.4421.

DOI:10.3748/wjg.v20.i15.4421
PMID:24764682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3989980/
Abstract

AIM

To investigate the expression and prognostic value of CCL2 in gastric cancer, as well as its relationship with tumor hypoxia.

METHODS

Tumor tissues from 68 gastric cancer patients (GC) were analyzed, and the expression of CCL2 and hypoxia-inducible factor 1 alpha (HIF-1α) in tumor tissues was detected by immunohistochemistry. Statistical evaluations that were used included univariate log-rank tests of Kaplan-Meier curves and multivariate Cox regression model analysis.

RESULTS

CCL2 was highly expressed in 66.2% (45/68) of gastric cancer specimens. The distribution of CCL2 expression in tumor tissue was consistent with that of HIF-1α. Patients with high CCL2 expression in GC had a lower overall survival rate [50.6 mo (95%CI: 44.44-56.93) vs 64.6 mo (95%CI: 60.27-68.94), P = 0.013].

CONCLUSION

CCL2 expression correlates closely with HIF-1α expression in gastric cancer. CCL2 may be an independent prognostic marker for GC.

摘要

目的

探讨趋化因子配体2（CCL2）在胃癌中的表达及其预后价值，以及其与肿瘤缺氧的关系。

方法

分析68例胃癌患者的肿瘤组织，采用免疫组化法检测肿瘤组织中CCL2和缺氧诱导因子1α（HIF-1α）的表达。采用Kaplan-Meier曲线的单因素对数秩检验和多因素Cox回归模型分析进行统计学评估。

结果

66.2%（45/68）的胃癌标本中CCL2高表达。CCL2在肿瘤组织中的表达分布与HIF-1α一致。胃癌中CCL2高表达的患者总生存率较低[50.6个月（95%CI：44.44-56.93）对64.6个月（95%CI：60.27-68.94），P = 0.013]。

结论

CCL2表达与胃癌中HIF-1α表达密切相关。CCL2可能是胃癌的一个独立预后标志物。