Joly P, Guillon J M, Mayaud C, Plata F, Theodorou I, Denis M, Debre P, Autran B
Laboratoire d'Immunologie Cellulaire et Tissulaire, UA CNRS 0186, Paris, France.
J Immunol. 1989 Oct 1;143(7):2193-201.
CTL specific for HIV have been described in lungs of infected patients at early stages of HIV disease. In order to characterize the evolution over time of HIV-specific CTL, we have analyzed the cytotoxic function and the cell surface phenotype of the alveolar lymphocytes from 41 patients at various stages of HIV disease. We demonstrated a progressive decline of alveolar anti-HIV CTL activity and detected Ts cells from the lungs of patients with advanced HIV disease. These alveolar T cells strongly suppressed the effector phase of anti-HIV CTL lysis. They lacked a marked specificity of function because they also block anti-HLA CTL response and were not restricted by the HLA-class-I transplantation Ag. They displayed the CD3, CD8, and HNK1 markers, were CD4 and CD16 negative, and lacked NK activity. The presence of Ts cells at late stages of HIV disease could thus partly explain the inefficiency of host defenses against HIV.
在HIV疾病早期阶段，已在受感染患者的肺部发现了针对HIV的细胞毒性T淋巴细胞（CTL）。为了表征HIV特异性CTL随时间的演变，我们分析了41例处于HIV疾病不同阶段患者的肺泡淋巴细胞的细胞毒性功能和细胞表面表型。我们证明肺泡抗HIV CTL活性逐渐下降，并在晚期HIV疾病患者的肺部检测到抑制性T细胞（Ts细胞）。这些肺泡T细胞强烈抑制抗HIV CTL裂解的效应阶段。它们缺乏明显的功能特异性，因为它们也会阻断抗HLA CTL反应，并且不受HLA - I类移植抗原的限制。它们表达CD3、CD8和HNK1标志物，CD4和CD16呈阴性，并且缺乏自然杀伤（NK）活性。因此，HIV疾病晚期Ts细胞的存在可以部分解释宿主对HIV防御的低效性。
