Zhu Chun-Chao, Liu Ye, Zhao Gang
Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China.
Oncol Lett. 2014 May;7(5):1427-1429. doi: 10.3892/ol.2014.1954. Epub 2014 Mar 7.
Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male presented with abdominal distension and a poor appetite, and was primarily diagnosed with a pancreatic mass. Abdominal ultrasonography, computed tomography and magnetic resonance imaging revealed a tumor in the body of the pancreas, which was closely attached to the gastric wall. Surgery was performed to excise the tumor. The tumor originated from the gastric cells and was ~17×15×16 cm in size. A diagnosis of GIST was confirmed by histomorphological and immunohistochemical findings. According to the postoperative findings, the tumor was classified to be in the high-risk group, for which the suggested treatment is imatinib. However, the patient was not treated with imatinib and, three years following surgery, the patient is alive with no evidence of tumor recurrence.
胃肠道间质瘤（GIST）是胃肠道最常见的间叶性肿瘤类型。肿瘤体积大往往意味着预后不良。本报告介绍了一例伴有囊肿改变的巨大外生性GIST病例，其预后良好，出人意料。一名78岁男性因腹胀、食欲差就诊，初步诊断为胰腺肿块。腹部超声、计算机断层扫描和磁共振成像显示胰腺体部有一个肿瘤，与胃壁紧密相连。行手术切除肿瘤。肿瘤起源于胃细胞，大小约为17×15×16 cm。组织形态学和免疫组化结果确诊为GIST。根据术后检查结果，该肿瘤被归类为高危组，建议的治疗方法是伊马替尼。然而，该患者未接受伊马替尼治疗，术后三年仍存活，无肿瘤复发迹象。
