Mossman S P, Leib D A, McCarthy K, Hart C A
Department of Medical Microbiology, University of Liverpool, U.K.
J Gen Virol. 1989 Sep;70 ( Pt 9):2507-12. doi: 10.1099/0022-1317-70-9-2507.
The DNA hypomethylating agent 5-azacytidine greatly increased the reactivation of alphaherpesvirus saimiri-1 (alpha HVS) from latently infected rabbit dorsal root ganglia, although it inhibited the virus yield and plaque formation efficiency of alpha HVS in Vero cells. 12-O-Tetradecanoylphorbol 13-acetate (a protein kinase C activator) and sodium n-butyrate both had a stimulating action on replication in Vero cells but did not affect the release of alpha HVS from latently infected rabbit dorsal root ganglia.
DNA 低甲基化剂 5-氮杂胞苷可显著提高潜伏感染兔背根神经节中赛米利里疱疹病毒 1 型（αHVS）的再激活率，尽管它会抑制 αHVS 在 Vero 细胞中的病毒产量和空斑形成效率。12-O-十四烷酰佛波醇 13-乙酸酯（一种蛋白激酶 C 激活剂）和丁酸钠对 Vero 细胞中的病毒复制均有刺激作用，但不影响 αHVS 从潜伏感染的兔背根神经节中的释放。
