Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Department of Pathology, Nippon Medical School Tama-Nagayama Hospital, Tokyo, Japan.
J Gastric Cancer. 2014 Mar;14(1):58-62. doi: 10.5230/jgc.2014.14.1.58. Epub 2014 Mar 31.
We report an extremely rare case of primary squamous cell carcinoma of the stomach. A 69-year-old man was admitted to our hospital with a 2-month history of dysphagia and tarry stools. Endoscopic examination revealed a cauliflower-shaped protruding mass along the lesser curvature of the gastric cardia. Biopsy of the lesion revealed squamous cell carcinoma of the stomach. Computed tomography revealed a thickened stomach wall and a mass protruding into the gastric lumen. Total gastrectomy with splenectomy, distal pancreatectomy, and Roux-en-Y reconstruction was performed, together with a lower thoracic esophagectomy via a left thoracotomy. Histopathological examination of the specimen revealed well-differentiated squamous cell carcinoma of the stomach. Postoperative follow-up was uneventful for the first 18 months. However, multiple liver metastases and para-aortic lymph node metastasis developed subsequently. Despite systemic combination chemotherapy, the patient died because of progression of the recurrent tumors. Here, we review the characteristics of 56 cases of gastric squamous cell carcinoma reported in Japan.
我们报告了一例极为罕见的胃原发性鳞状细胞癌。一名 69 岁男性因吞咽困难和柏油样便病史 2 个月而入院。内镜检查显示胃贲门小弯侧有一个菜花状隆起性肿块。病变活检显示胃鳞状细胞癌。计算机断层扫描显示胃壁增厚,肿块向胃腔突出。行全胃切除术+脾切除术、远端胰腺切除术和 Roux-en-Y 重建术,同时经左开胸行下胸段食管切除术。标本的组织病理学检查显示胃高分化鳞状细胞癌。术后前 18 个月随访无异常。然而,随后出现多发肝转移和腹主动脉旁淋巴结转移。尽管进行了全身联合化疗,但由于复发性肿瘤的进展,患者死亡。在此,我们回顾了日本报道的 56 例胃鳞状细胞癌的特征。