Pham Binh Van, Nguyen Duy Duc, Tran Manh Dai, Nguyen Thanh Duy, Thai An Duc, Nguyen Binh Tien, Le Ky Van, Nguyen Hoa Thi Thanh
Department of Abdominal Surgery 1, Vietnam National Cancer Hospital, Hanoi 100000, Vietnam.
Center for Pathology and Molecular Biology, Vietnam National Cancer Hospital, Hanoi 100000, Vietnam.
Oncol Lett. 2025 May 8;30(1):333. doi: 10.3892/ol.2025.15079. eCollection 2025 Jul.
Primary gastric squamous cell carcinoma (PGSCC) is a rare form of gastric malignancy. The etiology remains unclear and no standardized treatment protocol or consensus has been established. The current study presents a rare case of PGSCC treated by total gastrectomy and extended D2 lymphadenectomy, alongside a review of related clinical literature. A 57-year-old man was diagnosed with primary SCC located at the lesser curvature of the gastric body. The patient underwent a total gastrectomy and extended D2 lymphadenectomy. Postoperative pathology confirmed a moderately differentiated SCC with perineural invasion, classified as stage T4bN2M0. Treatment strategies for PGSCC remain controversial, underscoring the need for further studies with larger sample sizes to clarify therapeutic approaches.
原发性胃鳞状细胞癌（PGSCC）是一种罕见的胃恶性肿瘤。其病因尚不清楚，尚未建立标准化的治疗方案或共识。本研究报告了一例罕见的经全胃切除术和扩大D2淋巴结清扫术治疗的PGSCC病例，并对相关临床文献进行了综述。一名57岁男性被诊断为位于胃体小弯侧的原发性鳞状细胞癌。患者接受了全胃切除术和扩大D2淋巴结清扫术。术后病理证实为中度分化鳞状细胞癌伴神经侵犯，分类为T4bN2M0期。PGSCC的治疗策略仍存在争议，这突出表明需要进行更大样本量的进一步研究以明确治疗方法。
