叙利亚人群中的高危人乳头瘤病毒与人类癌症
High-Risk HPVs and Human Carcinomas in the Syrian Population.
作者信息
Al Moustafa Ala-Eddin, Ghabreau Lina, Akil Nizar, Rastam Samer, Alachkar Amal, Yasmeen Amber
机构信息
ABS Research and Development , Montreal, QC , Canada ; Oncology Department, McGill University , Montreal, QC , Canada ; Department of Mechanical Engineering, Concordia University , Montreal, QC , Canada ; Syrian Research Cancer Centre of the Syrian Society against Cancer , Aleppo , Syria.
Syrian Research Cancer Centre of the Syrian Society against Cancer , Aleppo , Syria ; Faculty of Medicine, Pathology Department, Aleppo University , Aleppo , Syria.
出版信息
Front Oncol. 2014 Apr 2;4:68. doi: 10.3389/fonc.2014.00068. eCollection 2014.
Human papillomavirus (HPV) infection is the most common sexually transmitted infection; persistent infection with high-risk types of HPV present a major risk factor for the initiation and progression of a variety of human carcinomas including cervical, colorectal, head, and neck (HN) as well as breast carcinomas. A huge number of studies investigated and reported the incidence of high-risk HPVs in these cancers worldwide particularly in the developed countries; therefore, two HPV prophylactic vaccines against the two most frequent high-risk HPV types (16 and 18) have been developed and used worldwide. However, there are very limited studies about the prevalence of HPVs in the developing countries especially in Africa and some states of the Middle East. In this mini review, we outline the presence of high-risk HPVs in human cervical, colorectal, HN as well as breast cancers in the Syrian population, which was recently explored for the first time by a Canadian/Syrian group.
人乳头瘤病毒（HPV）感染是最常见的性传播感染；高危型HPV的持续感染是包括宫颈癌、结直肠癌、头颈癌（HN）以及乳腺癌在内的多种人类癌症发生和进展的主要危险因素。大量研究调查并报告了全球尤其是发达国家这些癌症中高危型HPV的发病率；因此，针对两种最常见的高危HPV类型（16型和18型）的两种HPV预防性疫苗已在全球研发并使用。然而，关于发展中国家尤其是非洲和中东一些国家HPV流行情况的研究非常有限。在这篇小型综述中，我们概述了叙利亚人群中人类宫颈癌、结直肠癌、头颈癌以及乳腺癌中高危型HPV的存在情况，这是一个加拿大/叙利亚团队最近首次进行探索的。
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