Okamoto Kazuhiro, Nakamura Keiichiro, Matsuoka Hirofumi, Matsubara Yuko, Haraga Junko, Ogawa Chikako, Masuyama Hisashi
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama 700-8558, Japan.
Mol Clin Oncol. 2020 Apr;12(4):336-342. doi: 10.3892/mco.2020.1989. Epub 2020 Jan 29.
The aim of the present study was to determine whether chronic diseases (CD), such as hypertension, diabetes mellitus, dyslipidemia, heart diseases and cerebrovascular diseases, are occurrence risk factors and affect the survival of patients with gynecological cancers (GC). The correlations between CD and the characteristics and survival of 1,590 GC patients [685 with cervical cancer (CC), 613 with endometrial cancer (EM) and 292 with ovarian cancer (OV)] were investigated in the present study. Of the CD patients, 189 had CC (27.6%), 265 had EM (43.2%) and 72 had OV (24.7%). The incidence of CD increased with age in GC patients. The number of CD patients aged ≥70 years, was 8.6-fold higher in the CC group, 3.0-fold higher in the EM group, and 9.6-fold higher in the OV group compared with those aged <50 years. CD and excess body weight were associated with GC regardless of patient age. However, there was no correlation between CD and survival at any age in GC patients. These findings indicate that CD contribute to >24% of the occurrence risk factors in GC patients in Japan.
本研究的目的是确定诸如高血压、糖尿病、血脂异常、心脏病和脑血管疾病等慢性病（CD）是否为发生风险因素，并影响妇科癌症（GC）患者的生存。本研究调查了CD与1590例GC患者[685例宫颈癌（CC）、613例子宫内膜癌（EM）和292例卵巢癌（OV）]的特征及生存之间的相关性。在CD患者中，189例患有CC（27.6%），265例患有EM（43.2%），72例患有OV（24.7%）。GC患者中CD的发病率随年龄增长而增加。与年龄<50岁的患者相比，≥70岁的CD患者数量在CC组中高8.6倍，在EM组中高3.0倍，在OV组中高9.6倍。无论患者年龄如何，CD和超重均与GC相关。然而，在GC患者中，CD与任何年龄的生存均无相关性。这些发现表明，在日本，CD占GC患者发生风险因素的比例超过24%。
