Department of Clinical Laboratory, affiliated Nanhai Hospital of Southern Medical University, Foshan, 528200, Guangdong, China.
BMC Infect Dis. 2019 Jan 18;19(1):71. doi: 10.1186/s12879-019-3687-y.
To provide a scientific basis for the prevention and treatment of cervical cancer (CC), we investigated the distribution characteristics and genotypes of human papillomavirus (HPV) and the prevalence of multiple HPV infections in women of different ages seeking management for abnormal cytology in Foshan City.
Screening for the 21 genotypes of HPV was carried out in 9945 females seeking management of abnormal cervical cytology results using rapid flow-through hybridization of nucleic acid molecules. The overall prevalence, genotype distribution and age-specific prevalence were examined.
Our results indicate that the prevalence of overall, high-risk, intermediate-risk, and low-risk HPV infections was 13.5%, 12.1%, 1.3%, and 1.9%, respectively. Of the 1346 women who tested positive, 89.5% were positive for a single HPV genotype, and 10.5% were positive for ≥2 genotypes. The most frequently detected HPV genotype was HPV-16 (2.9%), followed by HPV-52 (2.9%), HPV-58 (1.5%), and HPV-CP8304 (1.0%). The highest infection prevalence was found in patients 21-30 years old (271/1670, 16.2%).
The prevalence of HPV infection in women seeking management for abnormal cytology in Foshan City is highest in the younger population (21-30 years old). Similar to most previous surveys, HPV-58 and HPV-52 infections are as common as HPV-16 infection.
为了为宫颈癌（CC）的预防和治疗提供科学依据，我们调查了不同年龄段因细胞学异常就诊的女性中 HPV 的分布特征和基因型以及多重 HPV 感染的流行情况。
使用核酸分子快速流动杂交技术对 9945 例因宫颈细胞学异常结果就诊的女性进行了 21 种 HPV 基因型的筛查。检查了总体流行率、基因型分布和年龄特异性流行率。
我们的结果表明，总体、高危、中危和低危 HPV 感染的流行率分别为 13.5%、12.1%、1.3%和 1.9%。在 1346 名阳性妇女中，89.5%为单一 HPV 基因型阳性，10.5%为≥2 种基因型阳性。最常检测到的 HPV 基因型是 HPV-16（2.9%），其次是 HPV-52（2.9%）、HPV-58（1.5%）和 HPV-CP8304（1.0%）。感染率最高的是 21-30 岁患者（271/1670，16.2%）。
在佛山因细胞学异常就诊的女性中 HPV 感染的流行率在年轻人群（21-30 岁）中最高。与大多数先前的调查一样，HPV-58 和 HPV-52 感染与 HPV-16 感染一样常见。
