Vecchio Giuseppe
Istituto Italiano di Tecnologia, Center for Biomolecular Nanotechnologies@UniLe , Arnesano, Lecce 73010 , Italy.
Nanotoxicology. 2015 Mar;9(2):135-7. doi: 10.3109/17435390.2014.911985. Epub 2014 Apr 28.
Drosophila was the most important model organism used in the fields of medicine and biology over the last century. Recently, Drosophila was successfully used in several studies in the field of nanotoxicology. However, only a part of its potential has been exploited in this field until now. In fact, apart from macroscopic observations of the effect due to the interaction between nanomaterials and living organism (i.e. lifespan, fertility, phenotypic aberrations, etc.), Drosophila has the potential to be a very useful tool to deeply analyze the molecular pathways involved in response to the interactions at nano-bio level. The aim of this editorial is to encourage the use of Drosophila by the different research groups working in the fields of nanotoxicology and nanomedicine, in order to define the effects induced by nanomaterials at molecular level for their subsequent exploitation in the field of nanomedicine.
果蝇是上个世纪医学和生物学领域最重要的模式生物。最近，果蝇已成功应用于纳米毒理学领域的多项研究。然而，到目前为止，其在该领域的潜力仅得到了部分开发。事实上，除了对纳米材料与生物体相互作用所产生的影响进行宏观观察（如寿命、繁殖力、表型畸变等）外，果蝇还有潜力成为深入分析纳米生物水平相互作用所涉及分子途径的非常有用的工具。这篇社论的目的是鼓励纳米毒理学和纳米医学领域的不同研究团队使用果蝇，以便确定纳米材料在分子水平上所诱导的效应，供其随后在纳米医学领域加以利用。
