Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
Mol Cell. 2014 Apr 24;54(2):208-9. doi: 10.1016/j.molcel.2014.04.009.
In the recent issue of Cell, Bonham et al. (2014) reveal that the sorting adaptor TIRAP regulates the assembly of the Myddosome upon Toll-like receptor activation from both the cell surface and endosomes through its promiscuous binding to lipids.
在最近一期的《细胞》杂志上,Bonham 等人(2014 年)揭示了衔接蛋白 TIRAP 通过其与脂质的混杂结合,从细胞表面和内体两个途径调节 Toll 样受体激活后 Myddosome 的组装。