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Promiscuity is not always bad.滥交并不总是坏事。
Mol Cell. 2014 Apr 24;54(2):208-9. doi: 10.1016/j.molcel.2014.04.009.
2
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.一种混杂的脂质结合蛋白使 Toll 样受体信号转导的亚细胞定位多样化。
Cell. 2014 Feb 13;156(4):705-16. doi: 10.1016/j.cell.2014.01.019.
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Innate immune signalling: TIRAP diversifies the sites of TLR signalling.固有免疫信号传导：TIRAP使Toll样受体（TLR）信号传导位点多样化。
Nat Rev Immunol. 2014 Apr;14(4):211. doi: 10.1038/nri3645. Epub 2014 Mar 7.
4
Sorting out Toll signals.梳理Toll信号
Cell. 2006 Jun 2;125(5):834-6. doi: 10.1016/j.cell.2006.05.014.
5
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.衔接分子TIRAP为Toll样受体提供信号特异性。
Nature. 2002 Nov 21;420(6913):329-33. doi: 10.1038/nature01180.
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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.磷酸肌醇介导的衔接蛋白募集控制Toll样受体信号传导。
Cell. 2006 Jun 2;125(5):943-55. doi: 10.1016/j.cell.2006.03.047.
7
Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.布鲁氏菌蛋白TcpB和宿主衔接蛋白TIRAP的Toll/白细胞介素-1受体（TIR）结构域的晶体结构揭示了分子模拟机制。
J Biol Chem. 2014 Jan 10;289(2):669-79. doi: 10.1074/jbc.M113.523407. Epub 2013 Nov 25.
8
Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling.基于数据的建模鉴定了 LPS/TLR4 信号转导中 TIRAP 非依赖性 MyD88 激活复合物和 Myddosome 组装策略。
Int J Mol Sci. 2020 Apr 26;21(9):3061. doi: 10.3390/ijms21093061.
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Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility.TLR1、TLR2、TLR4、TLR6和TIRAP基因多态性与疾病易感性的关联。
Immunol Res. 2015 Jun;62(2):234-52. doi: 10.1007/s12026-015-8640-6.
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Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies.MAL/Tirap衔接蛋白在病理学中的矛盾作用
Front Immunol. 2020 Sep 25;11:569127. doi: 10.3389/fimmu.2020.569127. eCollection 2020.
引用本文的文献
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A protocol for the systematic and quantitative measurement of protein-lipid interactions using the liposome-microarray-based assay.一种使用基于脂质体微阵列的测定法进行蛋白质-脂质相互作用的系统和定量测量的方案。
Nat Protoc. 2016 Jun;11(6):1021-38. doi: 10.1038/nprot.2016.059. Epub 2016 May 5.
2
Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells.小D-肽的酶促自组装：一种选择性杀伤癌细胞的多步过程
J Am Chem Soc. 2016 Mar 23;138(11):3813-23. doi: 10.1021/jacs.5b13541. Epub 2016 Mar 11.
3
The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway.Toll样受体4信号通路中TIR结构域信号小体的结构
Sci Rep. 2015 Aug 21;5:13128. doi: 10.1038/srep13128.
本文引用的文献
1
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.一种混杂的脂质结合蛋白使 Toll 样受体信号转导的亚细胞定位多样化。
Cell. 2014 Feb 13;156(4):705-16. doi: 10.1016/j.cell.2014.01.019.
2
Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily.结构洞察大型寡聚信号小体在 Toll 样受体-白细胞介素-1 受体超家族中的组装。
Sci Signal. 2012 May 29;5(226):re3. doi: 10.1126/scisignal.2003124.
3
Transforming binding affinities from three dimensions to two with application to cadherin clustering.将结合亲和力从三维转化到二维及其在钙黏着蛋白聚集中的应用。
Nature. 2011 Jul 27;475(7357):510-3. doi: 10.1038/nature10183.
4
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.TLR/IL-1R 信号转导中 MyD88-IRAK4-IRAK2 复合物的螺旋组装。
Nature. 2010 Jun 17;465(7300):885-90. doi: 10.1038/nature09121. Epub 2010 May 19.
5
MAPPIT analysis of TLR adaptor complexes.Toll样受体衔接蛋白复合物的MAPPIT分析
FEBS Lett. 2007 Feb 20;581(4):629-36. doi: 10.1016/j.febslet.2007.01.026. Epub 2007 Jan 18.
6
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.磷酸肌醇介导的衔接蛋白募集控制Toll样受体信号传导。
Cell. 2006 Jun 2;125(5):943-55. doi: 10.1016/j.cell.2006.03.047.
7
Binding specificity of Toll-like receptor cytoplasmic domains.Toll样受体胞质结构域的结合特异性。
Eur J Immunol. 2006 Mar;36(3):742-53. doi: 10.1002/eji.200535158.
8
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.衔接分子TIRAP为Toll样受体提供信号特异性。
Nature. 2002 Nov 21;420(6913):329-33. doi: 10.1038/nature01180.
9
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.TIRAP在激活由TLR2和TLR4共享的信号级联反应中起关键作用。
Nature. 2002 Nov 21;420(6913):324-9. doi: 10.1038/nature01182.
10
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.髓样分化因子88样衔接蛋白（Mal）是Toll样受体4信号转导所必需的。
Nature. 2001 Sep 6;413(6851):78-83. doi: 10.1038/35092578.
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