Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Mol Cell. 2014 Apr 24;54(2):309-20. doi: 10.1016/j.molcel.2014.03.039.
In recent years, our understanding of the mechanisms underlying colorectal carcinogenesis has vastly expanded. Underlying inflammation within the intestine, diet, and most recently, the gut microbiota, have been demonstrated to influence the development of colorectal cancer. However, since cancer is ultimately a genetic disease, these factors are thought to create genotoxic stress within the intestinal environment to promote genetic and epigenetic alterations leading to cancer. In this review, we will focus on how gut microbes intersect with inflammation, diet, and host genetics to influence the development of colon cancer.
近年来，我们对结直肠癌发生机制的理解有了极大的扩展。肠道内的炎症、饮食，以及最近的肠道微生物群，已被证实会影响结直肠癌的发展。然而，由于癌症归根结底是一种遗传性疾病，这些因素被认为会在肠道环境中产生遗传毒性应激，从而促进导致癌症的遗传和表观遗传改变。在这篇综述中，我们将重点讨论肠道微生物如何与炎症、饮食和宿主遗传相互作用，从而影响结肠癌的发生。
