抗生素-肠道微生物群-泌尿系统肿瘤轴的前沿进展
Cutting-Edge Advancements in the Antibiotics-Gut Microbiota-Urinary Tumour Axis.
作者信息
Wang Jie, Li Dengxiong, Wu Ruicheng, Feng Dechao
机构信息
Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Division of Surgery & Interventional Science, University College London, London, UK.
出版信息
Cell Prolif. 2025 May;58(5):e70023. doi: 10.1111/cpr.70023. Epub 2025 Mar 17.
Gut microbiota regulates urological tumors. Antibiotics induce dysbiosis, altering tumor progression/therapy: reducing carcinogen metabolism but impairing immunity. Specific bacteria enhance immune responses and combat endocrine resistance. Future research should unravel microbiota-cancer links and develop microbiome-targeted therapies to optimize outcomes while preserving diversity.
肠道微生物群调节泌尿系统肿瘤。抗生素会引发生态失调，改变肿瘤进展/治疗情况：减少致癌物代谢但损害免疫力。特定细菌可增强免疫反应并对抗内分泌抵抗。未来的研究应阐明微生物群与癌症之间的联系，并开发以微生物群为靶点的疗法，以在保持多样性的同时优化治疗效果。
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