Physiology of Exercise and Health Research Group, Faculty of Physical Education of University of Brasília, Campus Darcy Ribeiro, Brasília, Brazil; Federal Institute of Piauí, Floriano, Brazil.
Physiology of Exercise and Health Research Group, Faculty of Physical Education of University of Brasília, Campus Darcy Ribeiro, Brasília, Brazil; University of Brasília, Brasília, Brazil.
Arch Gerontol Geriatr. 2014 Jul-Aug;59(1):56-61. doi: 10.1016/j.archger.2014.03.012. Epub 2014 Apr 5.
The purpose of this study was to examine the association between sarcopenia and sarcopenic obesity (SO) with cardiometabolic risk factors in postmenopausal women. 149 volunteers (67.17±6.12 years) underwent body composition assessment using dual energy X-ray absorptiometry (DXA) and had analyzed blood samples collected for lipid profile, glucose metabolism and C-reactive protein (CRP). Sarcopenia was defined as an appendicular fat-free mass (AFFM) divided by height squared ≤5.45 kg/m(2) while SO was classified based on the residuals of a regression. Waist circumference (WC) and arterial blood pressure were also measured. Student's t-tests and correlations were used for analyses. Prevalence of sarcopenia and SO were respectively 16.8 and 21.5%. WC was significantly correlated with all the examined risk factors. AFFM relative to height squared was positively correlated with systolic blood pressure (SBP) and diastolic blood pressure (DBP), CRP, insulinaemia, HOMA score, and those classified as sarcopenic presented lower HOMA score when compared to nonsarcopenic. Regarding SO, although volunteers classified presented significantly higher fat mass (FM) and lower AFFM, it was not observed association with the examined risk factors. These findings support the association between WC and cardiometabolic risk factors in older women. In contrast, the approaches used to define sarcopenia and SO are not associated with cardiometabolic impairments.
本研究旨在探讨绝经后妇女中肌肉减少症和肌肉减少性肥胖（SO）与心血管代谢危险因素的关系。149 名志愿者（67.17±6.12 岁）接受了双能 X 射线吸收法（DXA）的身体成分评估，并对采集的血脂谱、葡萄糖代谢和 C 反应蛋白（CRP）的血液样本进行了分析。肌肉减少症定义为四肢去脂体质量（AFFM）除以身高的平方≤5.45 kg/m²，而 SO 则基于回归的残差进行分类。还测量了腰围（WC）和动脉血压。使用学生 t 检验和相关性分析进行分析。肌肉减少症和 SO 的患病率分别为 16.8%和 21.5%。WC 与所有检查的危险因素显著相关。AFFM 与身高的平方呈正相关，与收缩压（SBP）和舒张压（DBP）、CRP、胰岛素血症、HOMA 评分相关，与非肌肉减少症相比，肌肉减少症患者的 HOMA 评分较低。关于 SO，尽管分类的志愿者表现出明显更高的脂肪质量（FM）和更低的 AFFM，但未观察到与检查的危险因素有关。这些发现支持 WC 与老年妇女心血管代谢危险因素之间的关联。相反，用于定义肌肉减少症和 SO 的方法与心血管代谢损伤无关。
