Department of Biology, Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Ontario, Canada.
Trends Biochem Sci. 2014 May;39(5):227-32. doi: 10.1016/j.tibs.2014.03.003. Epub 2014 Apr 22.
Gasotransmitters are endogenously generated molecules of gas. Over the past decade we have come to realize that these gaseous signaling molecules are crucially important, being irreplaceable in wide biological applications. However, there are still many challenges for future gasotransmitter research to tackle. These include clarifying the interactions among gasotransmitters; understanding the significance of the cellular gasotransmitter signaling network; and adding new members to the modern family of gasotransmitters in addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Ammonia fulfills all criteria for being a gasotransmitter, and methane is another conceivable candidate. Following the original article postulating the concept of multiple gasotransmitters over a decade ago, this sequel article aims to further inspire interest and exploration into gasotransmitter research.
气体信号分子是内源性产生的气体分子。在过去的十年中，我们逐渐认识到这些气态信号分子至关重要，在广泛的生物学应用中是不可替代的。然而，未来的气体信号分子研究仍然面临许多挑战。这些挑战包括阐明气体信号分子之间的相互作用；理解细胞气体信号网络的重要性；以及除一氧化氮（NO）、一氧化碳（CO）和硫化氢（H2S）之外，为现代气体信号分子家族增添新成员。氨满足作为气体信号分子的所有标准，甲烷是另一个可以想象的候选者。在十多年前提出多种气体信号分子概念的原始文章之后，这篇后续文章旨在进一步激发人们对气体信号分子研究的兴趣和探索。
