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Insights into innovative therapeutics for drug-resistant tuberculosis: Host-directed therapy and autophagy inducing modified nanoparticles.

作者信息

Khoza Leon J, Kumar Pradeep, Dube Admire, Demana Patrick H, Choonara Yahya E

机构信息

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Science, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, Parktown 2193, South Africa.

School of Pharmacy, Faculty of Natural Sciences, University of the Western Cape, Cape Town, South Africa.

出版信息

Int J Pharm. 2022 Jun 25;622:121893. doi: 10.1016/j.ijpharm.2022.121893. Epub 2022 Jun 6.

DOI:10.1016/j.ijpharm.2022.121893
PMID:35680110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9169426/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/511c555a9b93/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/2b92578f88e9/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/579c11f245bf/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/d0536f7709b3/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/1e54b8fc9e1f/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/5f9e6307d8a0/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/35095c5d9f09/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/c2252dcbb1dc/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/511c555a9b93/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/2b92578f88e9/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/579c11f245bf/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/d0536f7709b3/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/1e54b8fc9e1f/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/5f9e6307d8a0/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/35095c5d9f09/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/c2252dcbb1dc/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd28/9169426/511c555a9b93/gr7_lrg.jpg

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Curr Res Pharmacol Drug Discov. 2022 Jan 18;3:100084. doi: 10.1016/j.crphar.2022.100084. eCollection 2022.
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Covid-19's Devastating Effect on Tuberculosis Care - A Path to Recovery.新冠疫情对结核病防治的毁灭性影响——恢复之路
N Engl J Med. 2022 Apr 21;386(16):1490-1493. doi: 10.1056/NEJMp2118145. Epub 2022 Jan 5.
3
Phosphatidylserine Liposomes Reduce Inflammatory Response, Mycobacterial Viability, and HIV Replication in Coinfected Human Macrophages.
用于对抗结核病的纳米级药物递送系统
Pharmaceutics. 2023 Jan 24;15(2):393. doi: 10.3390/pharmaceutics15020393.
磷脂酰丝氨酸脂质体可减少感染人类巨噬细胞中的炎症反应、分枝杆菌活力和 HIV 复制。
J Infect Dis. 2022 May 4;225(9):1675-1679. doi: 10.1093/infdis/jiab602.
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Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium Tuberculosis.壳聚糖-聚(乳酸-共-乙醇酸)纳米粒的理化性质和生物学评价作为一种针对分枝杆菌的宿主导向治疗。
J Pharm Sci. 2022 Feb;111(2):469-478. doi: 10.1016/j.xphs.2021.09.012. Epub 2021 Sep 14.
5
Manipulation of autophagy for host-directed tuberculosis therapy.通过调控自噬进行宿主导向性结核病治疗。
Afr J Thorac Crit Care Med. 2019 Jul 31;25(2). doi: 10.7196/AJTCCM.2019.v25i2.014. eCollection 2019.
6
Autophagy Induction as a Host-Directed Therapeutic Strategy against Infection.自噬诱导作为一种针对 感染的宿主定向治疗策略。
Medicina (Kaunas). 2021 May 23;57(6):522. doi: 10.3390/medicina57060522.
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Promotion of Anti-Tuberculosis Macrophage Activity by L-Arginine in the Absence of Nitric Oxide.精氨酸在没有一氧化氮的情况下促进抗结核巨噬细胞的活性。
Front Immunol. 2021 May 14;12:653571. doi: 10.3389/fimmu.2021.653571. eCollection 2021.
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