Smith Peter C, Cheng Debbie M, Allensworth-Davies Donald, Winter Michael R, Saitz Richard
Section of General Internal Medicine, Department of Medicine, Boston Medical Center and Boston University School of Medicine, 801 Massachusetts Avenue, Second Floor, Boston, MA 02118, United States.
Clinical Addiction Research and Education (CARE) Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center and Boston University School of Medicine, 801 Massachusetts Avenue, Second Floor, Boston, MA 02118, United States; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Third Floor, Boston, MA 02118, United States.
Drug Alcohol Depend. 2014 Jun 1;139:178-80. doi: 10.1016/j.drugalcdep.2014.03.027. Epub 2014 Apr 5.
People who consume unhealthy amounts of alcohol are more likely to use illicit drugs. We tested the ability of a screening test for unhealthy alcohol use to simultaneously detect drug use.
Adult English speaking patients (n=286) were enrolled from a primary care waiting room. They were asked the screening question for unhealthy alcohol use "How many times in the past year have you had X or more drinks in a day?", where X is 5 for men and 4 for women, and a response of one or more is considered positive. A standard diagnostic interview was used to determine current (past year) drug use or a drug use disorder (abuse or dependence). Oral fluid testing was also used to detect recent use of common drugs of abuse.
The single screening question for unhealthy alcohol use was 67.6% sensitive (95% confidence interval [CI], 50.2-82.0%) and 64.7% specific (95% CI, 58.4-70.6%) for the detection of a drug use disorder. It was similarly insensitive for drug use detected by oral fluid testing and/or self-report.
Although a patient with a drug use disorder has twice the odds of screening positive for unhealthy alcohol use compared to one without a drug use disorder, suggesting patients who screen positive for alcohol should be asked about drug use, a single screening question for unhealthy alcohol use was not sensitive or specific for the detection of other drug use or drug use disorders in a sample of primary care patients.
饮酒量不健康的人更有可能使用非法药物。我们测试了一项针对不健康饮酒的筛查测试同时检测药物使用情况的能力。
从初级保健候诊室招募了成年说英语的患者(n = 286)。他们被问到关于不健康饮酒的筛查问题:“在过去一年中,你有多少次一天喝了X杯或更多杯酒?”,其中男性的X为5,女性为4,回答一次或更多次被视为阳性。使用标准的诊断访谈来确定当前(过去一年)的药物使用情况或药物使用障碍(滥用或依赖)。还使用口腔液检测来检测近期常见滥用药物的使用情况。
针对不健康饮酒的单一筛查问题在检测药物使用障碍方面的敏感性为67.6%(95%置信区间[CI],50.2 - 82.0%),特异性为64.7%(95%CI,58.4 - 70.6%)。对于通过口腔液检测和/或自我报告检测到的药物使用情况,其敏感性同样较低。
尽管与没有药物使用障碍的患者相比,患有药物使用障碍的患者筛查不健康饮酒呈阳性的几率高出两倍,这表明对酒精筛查呈阳性的患者应询问其药物使用情况,但在初级保健患者样本中,针对不健康饮酒的单一筛查问题对于检测其他药物使用或药物使用障碍并不敏感或特异。