Zhang Pingping, Li Fang, Li Na, Zhu Qianqian, Yang Cuiling, Han Qunying, Chen Jinghong, Lv Yi, Yu Ling, Wei Ping, Liu Zhengwen
Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
Institute of Endemic Diseases, School of Medicine, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an 710061, Shaanxi, China.
Hum Immunol. 2014 Aug;75(8):709-14. doi: 10.1016/j.humimm.2014.04.010. Epub 2014 Apr 24.
Suppressor of cytokine signaling (SOCS)-1 is involved in viral infection through regulation of both innate and adaptive immunity. The SOCS1 gene polymorphisms may affect the outcome of viral infection. The relationship between SOCS1 polymorphisms and hepatitis B virus (HBV) infection has not yet been explored. This study genotyped SOCS1 rs243327 and rs33932899 polymorphisms in 477 patients with chronic HBV infection, 93 HBV infection resolvers and 215 healthy controls. In statistical analysis, p-values less than 0.05 in multiple comparisons were corrected by Bonferroni method and presented as pc. The results showed that the allele T-containing genotypes (CT+TT) of rs243327 were higher in HBV patients than resolvers and lower in resolvers than healthy controls although the difference was not significant. The allele T of rs243327 was significantly lower in resolvers than controls (p = 0.033). The genotype GC and allele C of rs33932899 were significantly less frequent in HBV patients than controls (pc < 0.001 and p < 0.001, respectively). The haplotype T/G of rs243327/rs33932899 was significantly more frequent in HBV patients than resolvers (pc < 0.001) or controls (pc = 0.009). These data indicate that SOCS1 polymorphisms might affect the susceptibility and outcome of HBV infection.
细胞因子信号转导抑制因子（SOCS）-1通过调节先天性免疫和适应性免疫参与病毒感染。SOCS1基因多态性可能影响病毒感染的结果。SOCS1多态性与乙型肝炎病毒（HBV）感染之间的关系尚未得到探讨。本研究对477例慢性HBV感染患者、93例HBV感染康复者和215名健康对照者的SOCS1 rs243327和rs33932899多态性进行了基因分型。在统计分析中，多次比较中p值小于0.05的用Bonferroni方法进行校正，并表示为pc。结果显示，rs243327含等位基因T的基因型（CT+TT）在HBV患者中高于康复者，在康复者中低于健康对照者，尽管差异不显著。rs243327的等位基因T在康复者中显著低于对照者（p = 0.033）。rs339,32899的基因型GC和等位基因C在HBV患者中的频率显著低于对照者（分别为pc < 0.001和p < 0.001）。rs243327/rs33932899的单倍型T/G在HBV患者中比康复者（pc < 0.001）或对照者（pc = 0.009）更常见。这些数据表明，SOCS1多态性可能影响HBV感染的易感性和结果。
