van Meurs Brian, Wiggert Nicole, Wicker Isaac, Lissek Shmuel
Clinical Science and Psychopathology Research Program, Department of Psychology, University of Minnesota-Twin City Campus, United States.
Clinical Science and Psychopathology Research Program, Department of Psychology, University of Minnesota-Twin City Campus, United States.
Behav Res Ther. 2014 Jun;57:29-37. doi: 10.1016/j.brat.2014.03.009. Epub 2014 Apr 3.
Fear-conditioning experiments in the anxiety disorders focus almost exclusively on passive-emotional, Pavlovian conditioning, rather than active-behavioral, instrumental conditioning. Paradigms eliciting both types of conditioning are needed to study maladaptive, instrumental behaviors resulting from Pavlovian abnormalities found in clinical anxiety. One such Pavlovian abnormality is generalization of fear from a conditioned danger-cue (CS+) to resembling stimuli. Though lab-based findings repeatedly link overgeneralized Pavlovian-fear to clinical anxiety, no study assesses the degree to which Pavlovian overgeneralization corresponds with maladaptive, overgeneralized instrumental-avoidance. The current effort fills this gap by validating a novel fear-potentiated startle paradigm including Pavlovian and instrumental components. The paradigm is embedded in a computer game during which shapes appear on the screen. One shape paired with electric-shock serves as CS+, and other resembling shapes, presented in the absence of shock, serve as generalization stimuli (GSs). During the game, participants choose whether to behaviorally avoid shock at the cost of poorer performance. Avoidance during CS+ is considered adaptive because shock is a real possibility. By contrast, avoidance during GSs is considered maladaptive because shock is not a realistic prospect and thus unnecessarily compromises performance. Results indicate significant Pavlovian-instrumental relations, with greater generalization of Pavlovian fear associated with overgeneralization of maladaptive instrumental-avoidance.
焦虑症的恐惧条件反射实验几乎完全集中在被动情绪的巴甫洛夫条件反射上,而非主动行为的工具性条件反射。需要引发这两种条件反射的范式来研究临床焦虑中巴甫洛夫异常所导致的适应不良的工具性行为。巴甫洛夫异常之一是恐惧从条件性危险线索(CS+)泛化到相似刺激。尽管基于实验室的研究结果反复将过度泛化的巴甫洛夫恐惧与临床焦虑联系起来,但尚无研究评估巴甫洛夫过度泛化与适应不良的过度泛化工具性回避之间的对应程度。当前的研究通过验证一种包括巴甫洛夫和工具性成分的新型恐惧增强惊吓范式填补了这一空白。该范式嵌入一款电脑游戏中,游戏过程中屏幕上会出现各种形状。一种与电击配对的形状作为CS+,而在无电击情况下呈现的其他相似形状作为泛化刺激(GSs)。在游戏过程中,参与者选择是否以表现变差为代价通过行为来避免电击。在CS+期间的回避被认为是适应性的,因为电击是一种实际可能性。相比之下,在GSs期间的回避被认为是适应不良的,因为电击并非现实的可能性,因此不必要地损害了表现。结果表明存在显著的巴甫洛夫 - 工具性关系,巴甫洛夫恐惧的更大泛化与适应不良的工具性回避的过度泛化相关。