Andrikopoulou Maria, Almalki Ahmad, Farzin Azadeh, Cordeiro Christina N, Johnston Michael V, Burd Irina
Integrated Research Center for Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Int J Dev Neurosci. 2014 Aug;36:25-31. doi: 10.1016/j.ijdevneu.2014.04.002. Epub 2014 Apr 24.
Over the past few decades, biomarkers have become increasingly utilized as non-invasive tools in the early diagnosis and management of various clinical conditions. In perinatal medicine, the improved survival of extremely premature infants who are at high risk for adverse neurologic outcomes has increased the demand for the discovery of biomarkers in detecting and predicting the prognosis of infants with neonatal brain injury. By enabling the clinician to recognize potential brain damage early, biomarkers could allow clinicians to intervene at the early stages of disease, and to monitor the efficacy of those interventions. This review will first examine the potential perinatal biomarkers for neurologic complications of prematurity, specifically, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and posthemorrhagic hydrocephalus (PHH). It will also evaluate knowledge gained from animal models regarding the pathogenesis of perinatal brain injury in prematurity.
在过去几十年中，生物标志物越来越多地被用作各种临床病症早期诊断和管理的非侵入性工具。在围产期医学中，具有不良神经学预后高风险的极早产儿存活率的提高，增加了对发现用于检测和预测新生儿脑损伤婴儿预后的生物标志物的需求。通过使临床医生能够早期识别潜在的脑损伤，生物标志物可以让临床医生在疾病早期进行干预，并监测这些干预措施的效果。本综述将首先研究早产神经并发症的潜在围产期生物标志物，具体而言，脑室内出血（IVH）、脑室周围白质软化（PVL）和出血后脑积水（PHH）。它还将评估从动物模型中获得的关于早产围产期脑损伤发病机制的知识。
