抑瘤 microRNA-224 通过靶向前列腺癌细胞中的致癌基因 TPD52 抑制癌细胞迁移和侵袭。
Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer.
机构信息
Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan; Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
Department of Urology, Teikyo University Chiba Medical Centre, Chiba, Japan.
出版信息
FEBS Lett. 2014 May 21;588(10):1973-82. doi: 10.1016/j.febslet.2014.04.020. Epub 2014 Apr 24.
Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA-224 (miR-224) is significantly downregulated in PCa tissues. Here, we found that restoration of miR-224 significantly inhibits PCa cell migration and invasion. Additionally, we found that oncogenic TPD52 is a direct target of miR-224 regulation. Silencing of the TPD52 gene significantly inhibits cancer cell migration and invasion. Moreover, TPD52 expression is upregulated in cancer tissues and negatively correlates with miR-224 expression. We conclude that loss of tumour-suppressive miR-224 enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic TPD52.
我们最近对前列腺癌 (PCa) 的 microRNA 表达特征进行了研究，结果显示 microRNA-224 (miR-224) 在 PCa 组织中明显下调。在这里，我们发现恢复 miR-224 的表达显著抑制了 PCa 细胞的迁移和侵袭。此外，我们发现致癌基因 TPD52 是 miR-224 调控的直接靶标。沉默 TPD52 基因可显著抑制癌细胞的迁移和侵袭。此外，TPD52 的表达在癌症组织中上调，并与 miR-224 的表达呈负相关。我们得出结论，肿瘤抑制性 miR-224 的缺失通过对致癌基因 TPD52 的直接调控，增强了 PCa 中癌细胞的迁移和侵袭。
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