巨细胞病毒微小核糖核酸
Cytomegalovirus microRNAs.
作者信息
Hook Lauren, Hancock Meaghan, Landais Igor, Grabski Robert, Britt William, Nelson Jay A
机构信息
VGTI, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA.
Department of Pediatrics, University of Alabama, Birmingham, AL 35294, USA.
出版信息
Curr Opin Virol. 2014 Aug;7:40-6. doi: 10.1016/j.coviro.2014.03.015. Epub 2014 Apr 23.
Abstract
The discovery that animals, plants and DNA viruses encode microRNAs (miRNAs) has transformed our understanding of the regulation of gene expression. miRNAs are ubiquitous small non-coding RNAs that regulate gene expression post-transcriptionally, generally by binding to sites within the 3' untranslated regions (UTR) of messenger RNA (mRNA) transcripts. To date, over 250 viral miRNAs have been identified primarily in members of the herpesvirus family. These viral miRNAs target both viral and cellular genes in order to regulate viral replication, the establishment and maintenance of viral latency, cell survival, and innate and adaptive immunity. This review will focus on our current knowledge of the targets and functions of human cytomegalovirus (HCMV) miRNAs and their functional equivalents in other herpesviruses.
摘要
动物、植物和DNA病毒编码微小RNA（miRNA）这一发现，改变了我们对基因表达调控的理解。miRNA是普遍存在的小非编码RNA，通常通过与信使RNA（mRNA）转录本的3'非翻译区（UTR）内的位点结合，在转录后调控基因表达。迄今为止，已在疱疹病毒家族成员中主要鉴定出超过250种病毒miRNA。这些病毒miRNA靶向病毒和细胞基因，以调节病毒复制、病毒潜伏的建立和维持、细胞存活以及先天性和适应性免疫。本综述将聚焦于我们目前对人类巨细胞病毒（HCMV）miRNA及其在其他疱疹病毒中的功能等效物的靶标和功能的认识。
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