Department of Cardiac Surgery, Centre Cardiologique du Nord, 93200 Saint-Denis, France.
Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.
Viruses. 2023 Sep 29;15(10):2027. doi: 10.3390/v15102027.
Aortic dissection is a clinicopathological entity caused by rupture of the intima, leading to a high mortality if not treated. Over time, diagnostic and investigative methods, antihypertensive therapy, and early referrals have resulted in improved outcomes according to registry data. Some data have also emerged from recent studies suggesting a link between Human Cytomegalovirus (HCMV) infection and aortic dissection. Furthermore, the use of microRNAs has also become increasingly widespread in the literature. These have been noted to play a role in aortic dissections with elevated levels noted in studies as early as 2017. This review aims to provide a broad and holistic overview of the role of miRNAs, while studying the role of HCMV infection in the context of aortic dissections. The roles of long non-coding RNAs, circular RNAs, and microRNAs are explored to identify changes in expression during aortic dissections. The use of such biomarkers may one day be translated into clinical practice to allow early detection and prognostication of outcomes and drive preventative and therapeutic options in the future.
主动脉夹层是一种临床病理实体，由内膜破裂引起，如果不治疗，死亡率很高。随着时间的推移，根据登记数据，诊断和检查方法、降压治疗和早期转诊已经导致了更好的结果。一些最近的研究数据也表明，人类巨细胞病毒（HCMV）感染与主动脉夹层之间存在关联。此外，microRNAs 的使用在文献中也越来越广泛。这些已经被注意到在主动脉夹层中发挥作用，早在 2017 年的研究中就发现了升高的水平。本综述旨在提供 microRNAs 作用的广泛而全面的概述，同时研究 HCMV 感染在主动脉夹层中的作用。探索长链非编码 RNA、环状 RNA 和 microRNAs 的作用，以确定在主动脉夹层过程中表达的变化。此类生物标志物的使用终有一天可能会转化为临床实践，以便早期发现和预测结果，并为未来提供预防和治疗选择。
