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侧链带有羧基的新型单羟基油菜素甾体类似物的生物活性

Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain.

作者信息

Kvasnica Miroslav, Oklestkova Jana, Bazgier Vaclav, Rarova Lucie, Berka Karel, Strnad Miroslav

机构信息

Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic.

Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 11, 78371 Olomouc, Czech Republic.

出版信息

Steroids. 2014 Jul;85:58-64. doi: 10.1016/j.steroids.2014.04.007. Epub 2014 Apr 21.

DOI:10.1016/j.steroids.2014.04.007
PMID:24769247
Abstract

Thirteen monohydroxylated brassinosteroids analogues were synthesized and tested for their biological activity in plant and animal systems. The cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard.

摘要

合成了13种单羟基油菜素甾体类似物，并在植物和动物系统中测试了它们的生物活性。以28-高表油菜素内酯为阳性对照，使用人正常细胞系和癌细胞系研究了产物的细胞毒性活性；以24-表油菜素内酯为标准品，通过菜豆第二节间试验确定了它们的油菜素内酯类活性。

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