解析人格的分子遗传学基础：从单胺到神经肽。
Disentangling the molecular genetic basis of personality: from monoamines to neuropeptides.
机构信息
Department of Psychology, University of Bonn, Germany; Laboratory of Neurogenetics, University of Bonn, Germany; Center for Economics & Neuroscience, University of Bonn, Germany.
Department of Psychology, University of Bonn, Germany; Laboratory of Neurogenetics, University of Bonn, Germany; Center for Economics & Neuroscience, University of Bonn, Germany.
出版信息
Neurosci Biobehav Rev. 2014 Jun;43:228-39. doi: 10.1016/j.neubiorev.2014.04.006. Epub 2014 Apr 23.
The present review/perspectives article provides a short overview of our current understanding of the molecular genetics of personality. In the first part, the most important gene candidates such as COMT or SLC6A4 gene are presented. Since several seminal review studies have recently been published on different facets of molecular genetics and personality/emotionality, we focus the second half of the present article on new relevant research directions. This includes a stronger focus on animal research based testing of candidate genes (e.g. neuropeptides such as oxytocin and vasopressin) and the use of á priori genotyping to increase statistical power. Moreover, we stress the importance of integrating cross-cultural data in future research designs and of inclusion of epigenetic measures in neuroscientifically oriented personality research. Finally, the Affective Neuroscience Personality Scales are introduced as a new promising tool for biologically oriented psychology/psychiatry research.
本文简要概述了目前对人格分子遗传学的认识。第一部分介绍了最重要的候选基因，如 COMT 或 SLC6A4 基因。由于最近有几篇关于分子遗传学和人格/情绪不同方面的重要综述文章发表，本文第二部分重点介绍了新的相关研究方向。这包括更加强调基于动物研究的候选基因（例如神经肽，如催产素和加压素）的测试，以及使用先验基因分型来提高统计能力。此外，我们强调了在未来研究设计中整合跨文化数据以及在神经科学导向的人格研究中纳入表观遗传测量的重要性。最后，介绍了情感神经科学人格量表，作为一种新的有前途的生物学导向心理学/精神病学研究工具。
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