肠道浆细胞样树突状细胞：与免疫和病理学的相关性。
Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology.
机构信息
Department of Biochemistry and Molecular Biology, University of Nevada School of Medicine, WPI, University of Nevada, Reno, 1664 N Virginia St. MS 0552, Reno, NV 89557, USA.
Department of Biochemistry and Molecular Biology, University of Nevada School of Medicine, WPI, University of Nevada, Reno, 1664 N Virginia St. MS 0552, Reno, NV 89557, USA; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
出版信息
Clin Immunol. 2014 Jul;153(1):165-77. doi: 10.1016/j.clim.2014.04.007. Epub 2014 Apr 24.
Abstract
Plasmacytoid dendritic cells (pDCs) are bone marrow-derived immune cells with the ability to express copious amounts of type I and III interferon (IFN) and can differentiate into antigen-presenting dendritic cells as a result of stimulation by pathogen-derived nucleic acid. These powerful combined functionalities allow pDCs to bridge the innate and adaptive immune systems resulting in a concerted pathogen response. The contribution of pDCs to gastrointestinal immunity is only now being elucidated and is proving to be a critical component in systemic immunity. This review will explore the immunology of pDCs and will discuss their involvement in human disease and tolerance with an emphasis on those in the gastrointestinal lymphoid tissue.
摘要
浆细胞样树突状细胞（pDCs）是骨髓来源的免疫细胞，具有表达大量 I 型和 III 型干扰素（IFN）的能力，并可在外源核酸刺激下分化为抗原呈递树突状细胞。这些强大的综合功能使 pDCs 能够连接先天免疫和适应性免疫系统，从而导致协同的病原体反应。pDCs 对胃肠道免疫的贡献现在才被阐明，并被证明是全身免疫的关键组成部分。本综述将探讨 pDCs 的免疫学特性，并讨论其在人类疾病和免疫耐受中的作用，重点是胃肠道淋巴组织中的 pDCs。
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