Cao Wei
Department of Immunology, Unit 901, 7455 Fannin, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.
J Clin Immunol. 2009 May;29(3):257-64. doi: 10.1007/s10875-009-9284-x. Epub 2009 Mar 6.
Plasmacytoid dendritic cells (pDCs) represent a unique and important immune cell population capable of producing large quantifies of type I interferon (IFN) in response to viruses as well as nucleic acid-containing complexes from the host. These rare and mysterious cells have been revealed by in-depth molecular characterization. Several innate sensors and signaling molecules enriched in pDCs allow their specialized innate immune functions. In addition, human pDCs use a group of surface receptors that, through activation of a B-cell receptor (BCR)-like signaling pathway, modulate type I IFN responses. It is clear now that pDC development is influenced by distinctive transcription factors that specify a unique lineage. CD4(+)CD56(+) hematodermic neoplasm of human pDC origin has been revealed in explicit molecular terms.
A detailed molecular description of pDCs helps us better define, understand, and track human pDCs in relation to their functions and physiological involvement.
浆细胞样树突状细胞（pDCs）是一种独特且重要的免疫细胞群体，能够响应病毒以及来自宿主的含核酸复合物而产生大量I型干扰素（IFN）。这些罕见而神秘的细胞已通过深入的分子表征得以揭示。pDCs中富集的几种天然传感器和信号分子赋予了它们特殊的天然免疫功能。此外，人类pDCs利用一组表面受体，通过激活类似B细胞受体（BCR）的信号通路来调节I型干扰素反应。现在很清楚，pDC的发育受特定独特谱系的独特转录因子影响。已从明确的分子角度揭示了源自人类pDC的CD4(+)CD56(+)血液肿瘤。
对pDCs的详细分子描述有助于我们更好地定义、理解和追踪人类pDCs及其功能和生理参与情况。
