Swiecki Melissa, Colonna Marco
1] Department of Pathology and Immunology, Washington University School of Medicine, 425 S. Euclid Avenue, St Louis, Missouri 63110, USA. [2] Janssen Research &Development, LLC, Spring House, Pennsylvania 19477, USA.
Department of Pathology and Immunology, Washington University School of Medicine, 425 S. Euclid Avenue, St Louis, Missouri 63110, USA.
Nat Rev Immunol. 2015 Aug;15(8):471-85. doi: 10.1038/nri3865. Epub 2015 Jul 10.
Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.
浆细胞样树突状细胞(pDC)是一种独特的树突状细胞亚群,专门负责产生I型干扰素(IFN)。pDC促进抗病毒免疫反应,并与以I型干扰素特征为特点的自身免疫性疾病的发病机制有关。然而,pDC也可诱导耐受性免疫反应。在本综述中,我们总结了pDC生物学领域的最新进展,重点关注调节pDC发育和功能的分子机制、其感知病原体和内源性核酸所涉及的途径、它们在黏膜部位的功能,以及它们在感染、自身免疫和癌症中的作用。