衰老对微小RNA的影响及病原体识别受体的调控
Effect of aging on microRNAs and regulation of pathogen recognition receptors.
作者信息
Olivieri Fabiola, Procopio Antonio Domenico, Montgomery Ruth R
机构信息
Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, INRCA-IRCCS Italian National Institute, Ancona, Italy.
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Curr Opin Immunol. 2014 Aug;29:29-37. doi: 10.1016/j.coi.2014.03.006. Epub 2014 Apr 25.
Immunosenescence is the multifactorial age-associated immune deteriorization that leads to increased susceptibility to infections and decreased responses to vaccines. Recent studies have shown a fundamental role for microRNAs (miRNAs) in regulating immune responses, and nearly all the miRNAs involved in immune regulation show modulation during aging. Aging-associated miRNAs are largely negative regulators of the immune innate response and target central nodes of aging-associated networks, in particular, NF-κB, the downstream effector of TLR signals that leads to induction of proinflammatory responses. Multiple miRNAs have been reported to share similar regulatory activity. Here we review miRNA regulation of human innate immune recognition in aging, including both activation and resolution of inflammation, critical issues in detection, and areas of active investigation into our understanding of immunosenescence.
免疫衰老指的是与年龄相关的多因素免疫功能衰退，这会导致对感染的易感性增加以及对疫苗的反应降低。最近的研究表明，微小RNA（miRNA）在调节免疫反应中发挥着重要作用，几乎所有参与免疫调节的miRNA在衰老过程中都表现出调节作用。与衰老相关的miRNA在很大程度上是免疫先天反应的负调节因子，并靶向衰老相关网络的核心节点，特别是核因子κB（NF-κB），它是Toll样受体（TLR）信号的下游效应器，可导致促炎反应的诱导。据报道，多种miRNA具有相似的调节活性。在此，我们综述了miRNA对衰老过程中人类先天免疫识别的调节作用，包括炎症的激活和消退、检测中的关键问题以及在我们对免疫衰老的理解方面积极研究的领域。
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