Liu Jingwei, He Caiyun, Xing Chengzhong, Yuan Yuan
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang 110001, China.
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang 110001, China.
Mutat Res. 2014 Jul;765:11-21. doi: 10.1016/j.mrfmmm.2014.04.008. Epub 2014 Apr 24.
Human genomic DNA is in a dynamic balance of damage and repair. Cells employ multiple and specific repair pathways, such as nucleotide excision repair (NER), as unrepaired DNA damage has deleterious consequences and could give rise to carcinogenesis. Gene polymorphisms play a crucial role in predicting the risk and prognosis of cancer. Polymorphisms of NER-related genes could alter the ability of NER to effectively monitor and repair DNA damage, and thus may be associated with genetic susceptibility, chemotherapeutic sensitivity and prognosis of cancer. In recent years, increasing studies have focused on the association between polymorphisms of NER genes and gastric cancer, the world's fourth most common cancer and the second most common cause for cancer-related death. Here we reviewed the recent studies on the associations between polymorphisms of NER genes and gastric cancer from perspectives of genetic susceptibility, chemotherapeutic sensitivity and prognosis.
人类基因组DNA处于损伤与修复的动态平衡中。细胞采用多种特定的修复途径，如核苷酸切除修复（NER），因为未修复的DNA损伤会产生有害后果并可能引发癌变。基因多态性在预测癌症风险和预后方面起着关键作用。NER相关基因的多态性可能会改变NER有效监测和修复DNA损伤的能力，因此可能与癌症的遗传易感性、化疗敏感性和预后相关。近年来，越来越多的研究聚焦于NER基因多态性与胃癌之间的关联，胃癌是全球第四大常见癌症，也是癌症相关死亡的第二大常见原因。在此，我们从遗传易感性、化疗敏感性和预后的角度综述了近期关于NER基因多态性与胃癌关联的研究。
