Ruan Tuo, Liu Weizhen, Tao Kaixiong, Wu Chuanqing
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Onco Targets Ther. 2020 Feb 28;13:1797-1807. doi: 10.2147/OTT.S239336. eCollection 2020.
Gastric cancer is one of the most common malignant tumors, and it is also one of the leading causes of cancer death worldwide. Because of its insidious symptoms and lack of early dictation screening, many cases of gastric cancer are at late stages which make it more complicated to cure. For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients. However, the drug-resistance to the chemotherapy restricts its effect and might lead to treatment failure. In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer. And we also want to find new approaches to counteract chemotherapy resistance and bring more benefits to the patients.
胃癌是最常见的恶性肿瘤之一，也是全球癌症死亡的主要原因之一。由于其症状隐匿且缺乏早期诊断筛查，许多胃癌病例处于晚期，这使得治疗更加复杂。对于这些晚期胃癌，手术、化疗、放疗和靶向治疗的联合治疗将给患者带来更多益处。然而，对化疗的耐药性限制了其疗效，可能导致治疗失败。在这篇综述文章中，我们讨论了近年来发现的胃癌耐药机制。我们还希望找到新的方法来对抗化疗耐药性，为患者带来更多益处。
