Yang Bi, Liang Bo, Liu Longqian, Liao Meng, Li Qian, Dai Yun, Zhao Haoxin, Zhang Yudong, Zhou Yifeng
*MS †PhD ‡MD Department of Optometry, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China (BY, LL, ML, QL); Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu, Sichuan, China (BL, YD, HZ, Y Zhang); and Vision Research Lab, School of Life Sciences, University of Science and Technology of China, Hefei, China (Y Zhou).
Optom Vis Sci. 2014 Oct;91(10):1271-7. doi: 10.1097/OPX.0000000000000253.
To investigate the effect on the contrast sensitivity function (CSF) of correcting the residual wavefront aberrations in myopic and keratoconic subjects wearing rigid gas permeable (RGP) contact lenses.
Seventeen eyes of 16 myopic subjects and 20 eyes of 19 keratoconic subjects were included in this study. All eyes were habitually corrected with RGP lenses. The residual aberrations of the RGP lens-wearing eyes were compensated by an adaptive optics (AO) system. The contrast sensitivities were measured through a 4-mm artificial pupil at spatial frequencies of 2, 4, 8, 16, and 32 cycles per degree (cpd) during RGP lens wear for the myopic and keratoconic groups, respectively. The CSF measurements were repeated with and without AO correction. Comparisons of contrast sensitivity at all spatial frequencies with and without AO correction were performed respectively for the myopic and keratoconic groups during RGP lens wear.
In the myopic RGP lens-wearing group, the differences in contrast sensitivity at each spatial frequency, with and without AO correction, were not significant (all p values > 0.05). In the keratoconic RGP lens-wearing group, the contrast sensitivities at all spatial frequencies with AO correction were higher than those without AO correction, but differences only at the low (2 cpd) and intermediate (4, 8, and 16 cpd) spatial frequencies were significant (p = 0.039, 0.005, 0.001, and 0.007).
The residual aberrations significantly reduced the contrast sensitivities at low and intermediate spatial frequencies for keratoconic RGP lens-wearing eyes but did not have any effect on the CSF for the myopic RGP lens-wearing eyes. Developing techniques that could more completely correct the wavefront aberrations may improve visual performance in keratoconus.
研究矫正近视和圆锥角膜患者佩戴硬性透气性（RGP）隐形眼镜时的残余波前像差对对比敏感度函数（CSF）的影响。
本研究纳入了16名近视患者的17只眼和19名圆锥角膜患者的20只眼。所有眼睛均习惯佩戴RGP镜片。佩戴RGP镜片眼睛的残余像差由自适应光学（AO）系统进行补偿。分别在近视组和圆锥角膜组佩戴RGP镜片期间，通过4毫米人工瞳孔在2、4、8、16和32周/度（cpd）的空间频率下测量对比敏感度。在有和没有AO矫正的情况下重复进行CSF测量。在佩戴RGP镜片期间，分别对近视组和圆锥角膜组在有和没有AO矫正的所有空间频率下的对比敏感度进行比较。
在近视RGP镜片佩戴组中，有和没有AO矫正时各空间频率下的对比敏感度差异均不显著（所有p值>0.05）。在圆锥角膜RGP镜片佩戴组中，有AO矫正时所有空间频率下测量的对比敏感度均高于没有AO矫正时，但是仅在低（2 cpd）和中（4、8和16 cpd）空间频率下差异具有统计学意义（p = 0.039、0.005、0.001和0.007）。
残余像差显著降低了圆锥角膜RGP镜片佩戴眼在低和中空间频率下的对比敏感度，但对近视RGP镜片佩戴眼的CSF没有任何影响。开发能够更完全矫正波前像差的技术可能会改善圆锥角膜患者的视觉性能。
