Bråne G, Gottfries C G, Blennow K, Karlsson I, Lekman A, Parnetti L, Svennerholm L, Wallin A
Department of Psychiatry and Neurochemistry, St. Jörgen's Hospital, Gothenburg University, Sweden.
Alzheimer Dis Assoc Disord. 1989 Fall;3(3):148-56. doi: 10.1097/00002093-198903030-00004.
Patients with Alzheimer disease (AD, onset less than 65 years of age, n = 13) and senile dementia of the Alzheimer type (SDAT, onset greater than or equal to 65 years of age, n = 28) were investigated for cerebrospinal fluid (CSF) content of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxy-phenylglycol (MHPG) and compared with a group of controls (n = 26). A geriatric rating scale, the Gottfries-Bråne-Steen scale, was used to assess impairment of motor performance, intellectual and emotional functioning, and symptoms common in dementia disorders. The HVA levels in CSF were significantly lower in the AD group than in the SDAT group and controls. MHPG was slightly but significantly increased in the SDAT group when compared with the controls. The HVA and 5-HIAA concentrations were correlated negatively with impairment of motor performance in the SDAT group; 5-HIAA correlated positively with impaired performance in the AD group; and 5-HIAA/HVA ratios were correlated positively with the performance variables. HVA correlated significantly and negatively with "impaired wakefulness" and "inability to increase tempo" in the SDAT group. 5-HIAA and the ratio 5-HIAA/HVA correlated significantly and positively with some items measuring intellectual and emotional impairment. In the AD group, "anxiety" and "fear-panic" correlated positively with 5-HIAA and "restlessness" with MHPG. The data indicate qualitative differences in the CSF monoamine pattern between AD and SDAT.
对阿尔茨海默病（AD，发病年龄小于65岁，n = 13）和阿尔茨海默型老年痴呆症（SDAT，发病年龄大于或等于65岁，n = 28）患者的脑脊液（CSF）中高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和3-甲氧基-4-羟基苯乙二醇（MHPG）含量进行了研究，并与一组对照者（n = 26）进行比较。使用一种老年评定量表——戈特弗里斯-布劳内-斯滕量表，来评估运动表现、智力和情感功能的损害以及痴呆症常见症状。AD组脑脊液中的HVA水平显著低于SDAT组和对照组。与对照组相比，SDAT组的MHPG略有但显著升高。在SDAT组中，HVA和5-HIAA浓度与运动表现损害呈负相关；在AD组中，5-HIAA与表现受损呈正相关；5-HIAA/HVA比值与表现变量呈正相关。在SDAT组中，HVA与“觉醒受损”和“无法加快节奏”显著负相关。5-HIAA和5-HIAA/HVA比值与一些测量智力和情感损害的项目显著正相关。在AD组中，“焦虑”和“恐惧-惊恐”与5-HIAA呈正相关，“坐立不安”与MHPG呈正相关。数据表明AD和SDAT之间脑脊液单胺模式存在质的差异。
